Sabzali Javadov received his M.D. degree in medical biochemistry from the Russian Medical University, Moscow, Russia, in 1983, and his Ph.D. degree in cardiology and biochemistry from the Russian Cardiology Center, Moscow, Russia, in 1986. Dr. Javadov was appointed as a Junior Faculty and rose through the ranks to become a Full Professor at the Azerbaijan Medical University, Baku, Azerbaijan (1994-2013). He worked at Magdeburg Medical University, Germany (1987), the National Institute of Cardiology, Hungary (1991), and the University of Bristol, UK (1997-2001) as a Visiting Scientist. In 2003, Dr. Javadov joined the Department of Physiology and Pharmacology at the University of Western Ontario, Canada. In 2009, he was recruited at the Department of Physiology, University of Puerto Rico, School of Medicine, USA, as a Faculty Member. Professor Javadov has a broad background in medical biochemistry, with specific training and expertise in cardiac pathophysiology and with a focus on the roles of mitochondria in ischemia-reperfusion and heart failure. His studies have been conducted on various model systems using in vivo (myocardial infarction in dogs and rats and alloxan-induced diabetes in rabbits), ex vivo (global ischemia-reperfusion in Langendorff-perfused isolated rat heart), and in vitro (hypertrophy and hypoxia/reoxygenation in cultured cells) models. He also used different pharmacological agents to prevent mitochondria-mediated cell death in cardiac diseases. Currently, Javadov laboratory evaluates crosstalk between mitochondrial ROS, permeability transition, and electron chain supercomplexes in mitochondria-mediated cardiac dysfunction during by ischemia-reperfusion and heart failure. He published over 70 peer-reviewed articles in scientific journals and books. Research in the Dr. Javadov laboratory is supported by the National Institutes of Health.