PhD, DrSc Kazima Bulayeva has done her biology and psychophysiology training in University of Rostov at Don, Russia, as well as in USSR Academy of Education, Moscow, Russia. Dr K Bulayeva is Member of Dagestan State National Academy of Sciences, Member of International Genetic Epidemiology Society and Member of International Scientific Corporation ENIGMA, as well as some other professional genetic and biomedical societies. Dr Bulayeva founded and managed genetic study among Caucasus indigenous ethnics in research institute of general genetics of Russian Academy of Sciences (1974-present). During long-term pioneer annual expedition study of these ethnics mostly located in remote highland regions, Dr Bulayeva and her collaborators discovered common genetic origin of 45 indigenous ethnics there, investigated inter-ethnics and within ethnics gene pool diversities, as well as genetic adaptation mechanisms to the severe highland environment of these ethnics during more than 10 K years of their history. Dr Bulayeva's study indicated that these ethnic populations have a high endogamy and high consanguineous marriages rates over hundreds generations that created genetically homogeneous gene pool with significant role of gene drift and selection pressure. One of most important factor of gene drift -ancestor effect along with endogamy and inbreeding created some rare genetic isolates with aggregation of certain complex diseases, such as neuropsychiatric (schizophrenia, major depressive disorder, BPD, ASD etc), cardiovascular disorder, certain types of cancer etc. Dr K Bulayeva suggested new cross-isolates approach with unified clinical and genetic methodologies for mapping genes of such complex diseases in these unique highly inbred genetic isolates with aggregation of same clinical phenotypes. The results obtained with such experimental design indicated its effectiveness in discoveries of whole set involved to ethio-pathogenesis of the diseases. Results of these original studies of Dr Bulayeva are published in about 200 peer reviewed books, articles and chapters of the books in Russia, US, UK, France, Germany, Turkey, Japan, including recent book published in Springer (Germany) and four articles in NATURE. Dr Bulayeva currently is continued her research activity with PhD students in Institute of general genetics of RAS and in Dagestan State University.
Genetic-Epidemiology; Molecular medicine; Brain diseases;