I am now a research scientist in Department of Ophthalmology and Visual Science at University of Louisville, Louisville, Kentucky, USA. Using autosomal dominant P23H retinitis pigmentosa swine model system, I am performing preclinical study of neurotrophic factor sufficiency or rhodopsin deficiency and/or sufficiency for cone rescue. Swine eye is similar to the human eye in terms of anatomy, vasculature, photoreceptor distribution and therefore provides an attractive animal model for research into retinal disease. The visual streak region of retina in swine is very much similar to fovea region of human retina. Swine model system will shade light on mechanism of cone rescue for day vision. After getting a national fellowship from Council of Scientist and Industrial Research (CSIR), I did my PhD in molecular biology from Centre of cellular and molecular biology (CCMB), Hyderabad India. After completion of my PhD, I was selected to pursue research in ribosome biology at University of California, San Diego. After this small transition, I joined as a postdoctoral researcher in retinal biology in Jacob retina centre, University of California, San Diego. Since then I have developed strong interest in retinal biology and pathology of disease progression. I have a significant contribution in understanding the inherited and age-related retinal degeneration by publishing many papers in peer-reviewed journals.
I am interested in understanding the genetics and mechanistic detail of photoreceptors and retinal pigmented epithelium degeneration and developing rational therapies for these blinding conditions. Using cutting edge molecular biology, biochemistry and genetics techniques, I wish to dissect molecular pathways for disease progression and further develop therapeutic major for retinal degeneration disease. Retinoid homeostasis in retina and retinal-pigmented epithelium is my area of research interest.