Dr. Nan-Shan Chang is the Professor and former Director of the Molecular Medicine Institute, National Cheng Kung University (NCKU) in Taiwan, and the Adjunct Professor with the SUNY Upstate Medical University and the NYS Institute for Basic Research in Developmental Disabilities, New York. Dr. Chang is most noted for his discovery of tumor suppressor WWOX in 2000. Dr. Chang's research has focused on the role of WWOX in cancer, immune cell maturation, and neural diseases.

Dr. Chang's group has been working WWOX-regulated cancer progression, immune cell differentiation, cell-to-cell recognition, neural development and neurodegeneration, and Zfra peptide inhibition of memory loss, proteinopathy and inflammatory reactions.