Dr. Uma S. Gautam is an Early Career Scientist awardee of Bill and Melinda Gates Foundation for his contribution to tuberculosis research. Dr. Uma Shankar earned his PhD degree in Life Sciences-Microbiology. In his postdoctoral training in infectious diseases- Mycobacterium tuberculosis (Mtb) at All India Institute of Medical Sciences, New Delhi, India as Scientist Pool Officer and Tulane National Primate Research Center- Tulane University serving as a Research Scientist (Postdoctoral) Tuberculosis Researcher). Dr. Gautam has been involved in his investigative career for approximately 10 years, and serving as a reviewer of PLoS One, Journal of Bacteriology, European Journal of Inflammation, International Journal of Immunopathology and Pharmacology, Future Microbiology, Life Science etc. He is currently investigating the role of IDO in TB pathogenesis in rhesus macaque model, identification of novel regulatory proteins/ molecules involved in TB pathogenesis; identification of novel sRNA in Mtb and their role in TB disease; role of ‘Dct’ pathway during pathogen-host interaction with the goal of translating these findings into better therapies for tuberculosis disease. Dr Gautam uses modern techniques such as RNA-sequencing, Immunofluorescence, animal tissue culture, flow cytometry etc.
Mycobacterium Host-pathogen interaction Rhesus macaque model of TB Two component sensor regulatory system and Signaling Macrophages:CD4 T cells Co-culture system Small RNA Lung Immunopathology Pharmacological TB drugs Autophagy RNAseq Hypoxia