Dr. Ksenia Kastanenka is an independent investigator at Massachusetts General Hospital and Harvard Medical School in Boston, MA. Ksenia received her Doctorate of Philosophy in Neuroscience from Case Western Reserve University under the mentorship of Dr. Lynn Landmesser. During doctorate training, Ksenia has developed her expertise in optogenetic control of neuronal circuits by studying and manipulating motoneuron pathfinding during development. Subsequently, Ksenia has joined the laboratory of Drs. Brian Bacskai and Brad Hyman in the Neurology Department at Massachusetts General Hospital and Harvard Medical School to apply optogenetics and multiphoton microscopy in order to dissect the role neural activity plays in onset and development of Alzheimers disease (AD). Ksenia’s work has identified perturbations in neuronal activity stemming from overexcitation within cortical circuits. In an attempt to prevent and/or reverse the disorder, Ksenia has studied the effects and mechanisms of action of AD therapeutics, such as anti-Abeta immunotherapy, aducanumab, and the novel multimodal botanical extract DA-9803. Ksenia strongly believes that these translational studies are important for getting effective therapies to patients.
Ksenia’s research interests lie in the sphere of aging with particular emphasis on Alzheimer’s disease (AD), studying circuitry disruption during the disease progression and mechanisms of action of potential therapeutics for AD. Ksenia is interested in optogenetic control of neuronal circuits. Circuit assembly during development is also of interest.