Vanessa Hallís PhD resulted in the production of the very first cloned cows in Australia. She was internationally recognized then for developing an enhanced somatic cell nuclear transfer technique and spotlighted in the media in 2005. In her first postdoc in England, she was producing the worldís first cloned human embryos for the purpose of human embryonic stem cell (ESC) lines, which received considerable media and scientific attention. She has also significantly advanced the field of pluripotent cell signalling in the pig with several internationally recognized articles. Her interest in applying ESC research for investigating disease began in Sweden and transferred from Parkinsonís disease to Alzheimerís disease (AD), upon moving to Denmark, where, as Associate Professor at the University of Copenhagen, has established a unique in-vitro cell model from a pig model of AD, which recapitulates some of the diseaseís pathology. She is currently acting as PI on two research projects in the field of AD. In the first, she is focused on improving the quality of neurons and production of more disease-relevant cell types produced from patient-derived induced pluripotent stem cells (iPSCs). Here, she is interested in producing stellate cells from AD-iPSCs, and is currently mapping the development of the entorhinal cortex in the pig in order to unleash important factors required to produce stellate cells in a dish.
In the second project, she is focused on uncovering novel mechanisms related to AD and is actively studying the role of the nucleolus in AD-derived induced pluripotent stem cells (iPSCs).