Dr. Mahendra P. Kashyap successfully completed his PhD from Jamia Hamdard University (New Delhi) in association with at Indian Toxicology Research Institute, Lucknow- India. His major research focus was to develop and validate the new and more sensitive human stem cell based in vitro models to understand the mechanisms involved in the pesticide-induced developmental neurotoxicity and therapeutic interventions. Following the isolation and characterization of human umbilical cord blood stem cells, these cells were allowed to differentiate into neuronal cells. At various time points of neuronal maturity; expression and activity of markers involved in neuronal development, injury and repair were studied in presence and absent of toxicants such as Organophosphate pesticide. After completion of PhD, he moved to United State at the University of Pittsburgh School of medicine as a Research Associate in 2012. During his postdoctoral training, he has been involved in deciphering the role of different neurotrophins such as NGF and BDNF in the Lower Urinary tract diseases such as Overactive Bladder/Interstitial Cystitis and Prostatitis in normal as well as in Spinal cord injured animals. Presently, his research is focused on development of antisense/ antagomirs based novel therapeutic interventions in preclinical models of Lower Urinary tract dysfunctions.
Dr. Kashyap`s research interest lies in the broad spectrum from In Vitro and In Vivo Toxicology/Neurotoxicology to Neuronal involvement of Lower Urinary tract dysfunction such as Overactive Bladder/Interstitial Cystitis, Prostatitis and therapeutic intervention by pharmacological agent such as Antisense/Antagomirs based therapies.