Apurba K. Bhattacharjee graduated with a Ph.D. degree in chemistry from the North Eastern Hill University, India in 1983. After completing postdoctoral research was at the “Institut de Topologie et de Dynamique des Systemes de l'Universite Paris 7, Paris, France with Professor J.-E. Dubois for three years, he joined Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD (USA). He served in the institute for over twenty years starting as a Senior Research Associate Fellow under National Research Council (USA) and retired as the Chief Molecular Modeler of WRAIR in early 2012. Currently, he is an Adjunct Associate Professor at the Department of Microbiology and Immunology at the School of Medicine, Georgetown University Medical Center, Georgetown University, Washington, D.C, USA. His research is in the field of computer assisted drug design and discovery (CADDD), particularly in the application of molecular electrostatic potentials (MEPs) in the design of novel therapeutics, specifically the “interaction pharmacophores” to elucidate biological activities. The goal of his research is to develop in silico 3D pharmacophore models from known biologically active compounds and use the models for virtual screening of compound databases to identify new active compounds. At WRAIR, his research supported the design and discovery of compounds against malaria, leishmaniasis, mosquitos (repellents) and counter agents for chemical and biological threat agents. His current research involves design and discovery of antiviral therapeutics against DENV, ZIKV and WNV. Very recently, his computer aided discovery research resulted in the discovery of 3 anti-Zika compounds (Antiviral Research 2016, in press). He also has over 25 years of experience in teaching and seminars for undergraduate and postgraduate students in India and Georgetown University. He has authored and coauthored 125 peer reviewed publications including four book chapters and 5 patents. SELECTED FEW PUBLICATIONS (from a total of 125 publications till 2016)  Bhattacharjee, A.K.; Marek, E.; Le, H.T.; Ratcliff, R.; DeMar, J.C.; Pervitsky, D.; Gordon, R.K. Discovery of non-oxime reactivators using an in silico pharmacophore model of reactivators for DFP-inhibited acetylcholinesterase. Eur. J. Med. Chem., 2015, 90, 209-220.  Bhattacharjee, A.K.; Pomponio, J.; Evans, S.A.; Pervitsky, D.; Gordon, R.K. Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods. Bioorg. Med. Chem., 2013, 21, 2651-2662.  Bhattacharjee, A.K. In silico stereoelectronic profile and pharmacophore similarity analysis of juvenile hormone, juvenile hormone mimics (IGRs) and insect repellents may aid discovery and design of novel arthropod repellents In: Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate. Series: QSAR in Environmental and Health Sciences; James Devillers, Ed.; CRC Press, Taylor & Francis Group: Boca Raton, 2013, Chapter 13, 297-331.  Bhattacharjee, A.K.; Marek, E.; Le, H.T.; Gordon, R.K. Discovery of non-oxime reactivators using an in silico pharmacophore model of oxime reactivators of OP-inhibited acetylcholinesterase. Eur. J. Med. Chem., 2012, 49, 229-238.  Gutteridge, C.E.; Hoffman, M.M.; Bhattacharjee, A.K.; Milhous, W.K.; Gerena, L. In vitro efficacy of 7-benzylamino-1-isoquinolinamine against Plasmodium falciparum related to the efficacy of chalcone. Bioorg. Med. Chem. Lett., 2011, 21, 786-789.  Bhattacharjee, A.K.; Kuča, K.; Musilek, K.; Gordon, R.K. In silico pharmacophore model for Tabun-inhibited acetylcholinesterase (AChE) reactivators: a study of their stereoelectronic properties. Chem. Res. Toxicol., 2010, 23, 26-36.  Bhattacharjee, A.K.; Gordon, J.A.; Marek, E.; Campbell, A.; Gordon, R.K. 3D-QSAR studies of 2,2-diphenylpropionates to aid discovery of novel potent muscarinic antagonists. Bioorg. Med. Chem., 2009, 17, 3999-4012.  Lee, P.J.; Bhonsle, J.B.; Gaona, H.W.; Huddler, D.P.; Heady, T.N.; Kreishman- Deitrick, M.; Bhattacharjee, A.K.; McCalmont, W.F.; Gerena, L.; Lopez-Sanchez, M.; Roncal, N.E.; Hudson, T.H.; Johnson, J.D.; Prigge, S.T.; Waters, N.C. Targeting the fatty acid biosynthesis enzyme, ß-ketoacyl – acyl carrier protein synthase III (PfKASIII) in the identification of novel antimalarial agents. J. Med. Chem., 2009, 52, 952-963.  Bhattacharjee, A.K. In silico 3D pharmacophores for aiding discovery of the Pfmrk (Plasmodium cyclin-dependent protein kinases) specific inhibitors for therapeutic treatment of malaria. Expert Opin. Drug Discov., 2007, 2(8), 1115-1127.  Bhattacharjee, A.K.; Hartell, M.G.; Nichols, D.; Hicks, R.P.; van Hamont, J.E.; Milhous, W.K. In: In silico three dimensional pharmacophore models to aid the discovery and design of new antimalarial agents, Proceedings of the 1CCS Computational Science - 6th International Conference, Part I,
Goal of his research is to develop in silico 3D pharmacophore models from known biologically active compounds and use the models for virtual screening of compound databases to identify new active compounds.