Dr. Tingting Gu grew up in a beautiful town in east of China with a dream to become a doctor, not a scientist. In a cell biology class at the medical school of Suzhou, she was fascinated by science and decided to pursue graduate school in Biology. After flying over the Pacific Ocean, she joined Dr. Randall Hewes’ lab at the University of Oklahoma, where she studied neuroscience and genetics in Drosophila. Dr. Gu’s previous research interest is in Tuberculosis disease, specially in Mycobacterium tuberculosis pathogenesis and roles of macrophage in immune response. Now, she is a research scientist at the University of Oklahoma and investigating the genetics and molecular pathways controlling synaptic transmission and remodeling and plasticity of neuroendocrine cells. Neuronal remodeling is an essential step in shaping neuronal connections to establish fully mature and functional nervous systems. By applying genetics, genomic, and behavior analyses, Dr. Gu and colleagues characterized the neuronal remodeling process in Drosophila melanogaster and identified various genes and signals involved in this critical process. By studying the remodeling of neuroendocrine cells, Dr. Gu hopes to understand how neuroendocrine cells maintain their plasticity in response to various internal and external stimuli.
Tuberculosis disease, genetics and genomics, cell growth and differentiation, neuroendocrine signaling, signaling transduction, and synapse plasticity