The focus of Dr. Sanchari Banerjee’s area of research includes understanding the different biological systems using the conventional and fast-evolving technique of X-ray crystallography. During her Ph.D., she studied one of the most important enzymes, adenylosuccinatelyase (ASL) that is part of the purine biosynthetic pathway in most organisms. She had characterized this enzyme structurally and functionally from three bacterial species: Mycobacterium tuberculosis, Mycobacterium smegmatis and Salmonella typhimurium. These studies revealed significant catalytic property differences among various ASLs.
Another important topic of her research was to structurally characterize the proteases of plant viruses, which helps in processing of the viral polyprotein into individual functional proteins that are important for pathogenesis.In her postdoctoral research she trained herself in more advanced fields of X-ray crystallography including X-ray free electron lasers. Working on pathogenic bacterial systems continues to fascinate her. Dr. Sanchari Banerjee is also involved in other interesting projects like ‘understanding evolution of viviparity in cockroaches’ using biophysical methods.
Understanding the different biological systems using the conventional and fast-evolving technique of X-ray crystallography; Study of adenylosuccinatelyase (ASL); Mycobacterium tuberculosis, Mycobacterium smegmatis and Salmonella typhimurium.