Dr. Chao Chen is now a Postdoctoral Research Fellow under the guidance of Dr. Véronique Dartois at Public Health Research Institute, New Jersey Medical School, Rutgers University. She is interested in bacterial efflux pumps, antibiotic resistance, and antimicrobial discovery. She studies drug distribution and drug-drug interactions in mammalian cells and bacterial cultures. At the same time, she executes pharmacokinetics, pharmacodynamics, tissue distribution, and efficacy studies in animal models. In addition, she is also developing a synergy-based therapy for treating Tuberculosis.
She received her Ph.D. in Biology from Northeastern University under the guidance of Dr. Kim Lewis. Her dissertation is “Novel Therapeutic Approaches Targeting Clostridium difficile”. She developed a high-throughput screen (HTS) method to select for C. difficile-specific antimicrobials, and identified a number of compounds killing C. difficile specifically. She also evaluated the potential of the natural product berberine in treating C. difficile infection.
Dr. Chen has published in internationally circulated top journals in her field (with more than 300 citations), such as Nature, Nature Medicine, The Journal of Experimental Medicine, ACS Infectious Diseases, Bioorganic and Medicinal Chemistry Letters, Antimicrobial Agents and Chemotherapy, and etc. She has also presented her findings at professional conferences.
Bacterial efflux pumps; Antibiotic resistance; Antimicrobial discovery.