Dr. Theodorus Sjouke Plantinga (1983), PhD holds a master degree in Biomedical Sciences from Radboud University, Nijmegen, The Netherlands. In 2012, he successfully completed his PhD thesis at Radboud University Medical Center, Nijmegen, The Netherlands cum laude by studying the role of genetic variation in development, severity and clinical progression of immune-mediated diseases. His research focuses on immune and inflammatory pathways including molecular pattern recognition, autophagy and modulation of cytokine release. He worked on several projects covering the following topics: infectious diseases, Crohn’s disease, rheumatoid arthritis and cancer. In the field of infectious diseases and immune tolerance he is an expert in bacterial and fungal micro-organisms with ongoing research into probiotics, tuberculosis, Lyme disease, Crohn’s disease, candidiasis and aspergillosis. These studies encompass pattern recognition by antigen presenting cells, innate immune responses covering phagocytosis, autophagy and cytokine production and T-cell mediated adaptive immune responses. Furthermore, he studies the role of host genetic variation in susceptibility to these infectious diseases in order to identify important susceptibility genes and to uncover crucial immune mechanisms that prevent and effectively combat infectious diseases.
Pattern recognition by antigen presenting cells; Innate immune responses; Phagocytosis; Autophagy; Antigen presentation; Cytokine production; T-cell mediated adaptive immune responses; Tuberculosis; Lyme disease; Crohn’s disease; Candidiasis; Aspergillosis; Probiotics; Immunogenetics.