Dr. E Shyam P Reddy carriedout his Ph.D. works at the Center for Cellular and Molecular Biology, Hyderabad, India. Part of Ph.D. work was also carried out at Max Planck Institute for Biophysical Chemistry, Gottingen, West Germany. His Ph.D. work was published as two papers (back to back) in the prestigious Nature journal for which he was awarded National Young Scientist award by the Prime minister of India. He received First Margaret Memorial award, UK to carryout research at NIH. He obtained postdoctoral training in molecular biology at Yale University, CT (Prof. Weissman, PNAS member). His contemporary colleagues at Yale University include Drs Francis Collins and Veena Rao. He discovered and cloned several cancer genes/oncogenes (close to 20 genes) and studied their functions. The most notable genes discovered by him include ERG-1, ERG-2, ERG-3 and human FLI-1genes. Drs Reddy and Rao named the gene as ERG (ETS Related Gene, published in prestigious journals Science and PNAS). ERG is a transcriptional factor, endothelial permeability factor and also a stem cell factor and is involved in 50-80% of Prostate cancers, Ewing sarcoma and also leukemias (AML). Other notable ETS genes discovered and studied by Dr. Reddy include human Fli-1 (involved in 80% of Ewing family of tumors, Leukemias and Prostate cancer), EWS-Fli-1 (involved in 80% of Ewing Sarcoma, Pediatric cancer), EWS-erg (involved in Ewing Sarcoma), TLS-erg (involved in Acute Myeloid Leukemia), EWS (involved in multiple cancers), TLS/FUS (involved in multiple cancers), ELK-1 (Drs Reddy and Rao named this gene as ETS Like Gene, published in prestigious journals Science and Nature) and EWS-ATF-1 (malignant Melanoma of Soft Parts/Clear cell sarcoma). In collaboration with Dr Rao, he also identified BRCA1a and BRCA1b.
Dr. Reddy and his group have also discovered novel POST-TRANSLATIONAL mechanism mediated by BRCA2 in Breast Cancer cells that will have global effect on the Gene Expression, Differentiation, Protein turnover, Cell Death, Cancer and other Human diseases.
Dr. Reddy and his group have shown that ERG and FLI-1 proteins involved in several cancers are responsible for making cancer cells resistant to chemo-therapeutic agents. They are targeting these onco-proteins or their functions to develop novel targeted therapeutic agents. Using this strategy, they have developed several novel therapeutic agents (patent being submitted) that target Prostate cancer, Ewing Sarcoma, Breast cancer (including Triple Negative Breast Cancer), Pancreatic cancer, Ovarian cancer, cervical cancer, colorectal cancer, pancreatic cancer etc. These small molecules appear to be targeted therapeutic agents with no or little effect on normal cells. Dr Reddy received a grant from DOD to do research on two targeted therapeutic agents against prostate cancer. Dr Reddy and his colleagues have also shown that anti-epileptic drug Valproic acid (VPA) targets ERG-positive Prostate cancers and Ewing Sarcoma and identified the molecular mechanism of action of VPA on ERG/Fli-1 associated cancers. Recently, they have identified novel ways by which ERG/ETS oncoproteins target different signaling pathways that leads to prostate and other cancers (leukemias, lymphomas and sarcomas). Recently, Dr Reddy and his colleagues have identified novel molecular mechanism of activation of TGF beta –signaling pathway by ERG oncoprotein in prostate cancer.
HONORS and AWARDS: The Prestigious MAHATMA GANDHI PRAVASI GOLD MEDAL at the HOUSE OF LORDS, PARLIAMENT, LONDON, UK; LIFETIME ACHIEVEMENT AWARD by IIFS at New Delhi; prestigious Bharat Award for Excellence; the prestigious RASHTRYA JEWEL AWARD and GOLD MEDAL by FFI; Mother Teresa Excellence Award by the Integrated Council for Socio-Economic Progress; International Goldstar Award, 2012 at Bangkok; Prestigious Best Personalities of India Award and Gold Medal; Prestigious Bharat Excellence Award and Gold Medal; Prestigious Super Achievers of India Award and Gold Medal; CPDR Saturday Distinguished Visiting Professor Recognition Award, BHARAT GAURAV AWARD ( Pride of India Award) from Union Minister, Government of India and IIFS, the GLORY of INDIA AWARD, GCC Distinguished Cancer Scholar Award (received from the Governor, Georgia, USA), TAMA Award for outstanding efforts, services and leadership in the field of Medicine, MSM Dean's Outstanding Research award, ATA award for Excellence in Science, USA; INSA Young Scientist Award from the Prime Minister of India, Outstanding Grantsmanship Award and induction into the million dollars club of Drexel University, Twice recipient of Swebelius Cancer Research Award at Yale University, First Margaret Memorial award, UK.
Prostate cancer; Pediatric cancer; Ewing Sarcoma; Gene Expression etc.