Dr. Ghosh received his BVSc (DVM equivalent) from WBUAFS, West Bengal, India, his M.S. from University of North Texas, Texas, USA, and his Ph.D from University of Wisconsin-Madison, Madison, USA. His doctoral work used gene and genome-wide analyses to decipher the virulence of Mycobacteriumavium subsp. Paratuberculosis (Map), the causative agent of Johne’s disease, a chronic enteric infection in ruminants and further understand the mechanisms of bacterial adaptation to infection. His doctoral studies also provided the rational basis for using virulence-attenuated mutant strains of Map to develop improved vaccines that elicit robust immunity. At the end of his graduate studies, he worked at a start-up company, Pan Genome Systems Inc. before joining Harvard Medical School as a Research Fellow.
Dr. Ghosh is a highly-experienced researcher in the fields of microbial pathogenesis and host-pathogen interactions. His current research areas include study of host-pathogen interactions, with an emphasis on elucidating the molecular mechanisms of intracellular pathogenesis using Listeria monocytogenes (Lm) as a model intracellular pathogen. Another aspect of his research interests is to understand fundamental aspects of adaptive immunity and T cell-mediated protection to intracellular pathogens in humans and animals. His scientific research has been supported by USDA and NIH grants and results are published in many peer reviewed scientific journals. He is a member of American Society of Microbiology, and American Association for the Advancement of Science.
Listeria monocytogenes; Listeriosis; Mycobacteriumavium subsp. paratuberculosis; Johne’s disease; host-pathogen relationship; Bacterial invasion of brain; Functional Genomics; Molecular and cellular Biology; Microbiology; Microscopy; Intracellular delivery of monoclonal antibodies.