Dr. Vitaly Viktorovich Kadyshev, a certified geneticist and ophthalmologist of the highest qualification, is a highly-skilled specialist in hereditary eye diseases. Vitaly Kadyshev has been working in healthcare since 2001 and has been engaged in medical activity since 2004. Currently, he successfully applies his practical medical knowledge in research and educational activities. In 2011, V.V. Kadyshev completed a dissertation in the Genetics and Ophthalmology special subjects. The topic of the dissertation: Epidemiology and Clinical-Genetic Features of Isolated Hereditary Ophthalmic Pathology in the Kirov Region. As part of the work, an algorithm for the interdisciplinary examination of patients with hereditary eye diseases has been developed; the results have been practically implemented in applied healthcare; the peculiar features and level of the disease burden of the subject of the Russian Federation have been determined, which helped to adjust therapeutic and preventive measures at the regional health level. Nowadays, Vitaly Kadyshev continues clinical and research studies of hereditary eye pathologies (syndromic, isolated) and genetic heterogeneity of hereditary human diseases. He has been identifying features of the clinical course of hereditary eye diseases as well as genotype-phenotype correlations. Vitaly Kadyshev is directly involved in the physical examination of patients from various regions of the Russian Federation. In 2021, V.V. Kadyshev on the basis of the Federal State Budgetary Scientific Institution Research Center for Medical Genetics created a Research and Clinical Center for the Genetics of Eye Diseases: there are no other centers of this kind in Russia. Since then, he has been the Head of it. During his career as a practicing physician, Vitaly Kadyshev has examined more than 10,000 families with rare and hereditary diseases, which indicates the diversity and flexibility of his practical skills, a wide range of his experience, and high level of proficiency and qualification. V.V. Kadyshev is an expert in the working group on gene therapy for inherited retinal diseases which are related to orphan diseases (Leber congenital amaurosis, retinitis pigmentosa). Thanks to his clinical, research, and managerial abilities, Vitaly Kadyshev has formed a patient pool and received full approval to conduct the first gene therapy in Russia for patients with a rare eye disease, Leber congenital amaurosis, type 2, which was eventually launched on November 29, 2021. V.V. Kadyshev regularly attends local and foreign scientific and clinical congresses, conventions, and conferences where he shares his practical skills and best practices applied in healthcare. V.V. Kadyshev is the only Russian specialist who has been included in a working group of European and US specialists that develops diagnostics and therapy for the orphan disease of choroidea, choroideremia (ICRN Clinical Trials Working Group). V.V. Kadyshev is a permanent guest speaker at Ghent University (Belgium) as part of a mentoring program for ophthalmologists and geneticists. V.V. Kadyshev together with co-authors has registered the first and as of now the only database in Russia on patients with aniridia, a genetic eye malformation. Vitaly Kadyshev is a full member of the Association of Medical Geneticists, the Russian Society of Medical Geneticists, the Association of Ophthalmologists of Russia, and the European Society of Human Genetics (ESHG), the European Society of Retina Specialists (EURETINA). V.V. Kadyshev is one of the authors of the patent for the invention Method of Differential and Confirming Molecular-Genetic Diagnosis of Congenital Aniridia and WAGR Syndrome. The WAGR Syndrome database and a software solution, a graphical interface of the WAGR Syndrome database, developed by Vitaly Kadyshev have been registered and implemented in practical healthcare. During his work, V.V. Kadyshev has published more than 100 printed works in leading domestic and foreign medical publications. He is a co-author of a guidance manual on mucopolysaccharidosis and an author of a chapter in the Educational Guide Methodology of Genetic and Epidemiological Study of Inherited Diseases and Congenital Malformations. He is a member of the team of authors of guidelines on aniridia and inherited retinal diseases. During his active and fruitful work, V.V. Kadyshev has received the unique research and clinical experience of a practicing physician and a researcher. The data obtained in his studies are being actively introduced into applied healthcare in Russia, which improves the quality of life of the domestic residents and has a positive effect on the socioeconomic vectors of the country. V.V. Kadyshev, being the Head of the Ophthalmic Genetics Department of the Educational Department in FSBSI Research Center for Medical Genetics, regularly undergoes educational cycles of advanced training for doctors, gives lectures and practical seminars for residents and g
Dr. Kadyshev Vitaly Viktorovich's research interests are pharmaceutical drug discovery research/development experience covering Ophthalmology, Genetics, and Neuroscience.