Tamara Gulic is an assistant professor at the Department of Physiology and Immunology in the Medical Faculty, University of Rijeka, where she obtained her Ph.D. degree in Biomedicine. She has 14 years of working experience in the field of cellular physiology and immunology research. Currently, the focus of her research is the immunomodulatory mechanisms of macrophages and NK cells in the tumors microenvironment. Tamara Gulic participated in the realization of several scientific projects, first as a young research fellow and now as a principal investigator. She is a mentor of two Ph.D. students. She has presented her work at numerous international conferences and has published 14 articles in peer-reviewed scientific journals, indexed in the CC database. Tamara Gulic is skilled in planning, development, and execution of high-impact research in biomedical science. She is a member of several associations related to her research field.
The focus of Dr. Tamara Gulic's current research is the immunomodulatory role of antigen-presenting cells in tumors' microenvironment. Namely, tumor cells have a highly developed immunoevasive strategy. Upon invasion, they reorganize the microenvironment system of the host and downregulate surface MHC class I molecules with the ultimate goal to replicate and propagate. During macrophage/NK cell interaction, mediators from local microenvironment-shaped macrophages cannot efficiently multiply or equip NK cells with the cytotoxic mediators. Understanding this immunological mechanism by which tumors can escape surveillance is one of the main goals of my research.