Dr. Shweta Kailasan received her PhD from University of Florida (USA) in Biomedical Sciences. She also holds B.S. and M.S. in Biotechnology from Claflin University (USA) and Johns Hopkins University (USA), respectively. Dr. Kailasan has 8 years’ experience as a structural biologist and biochemist. Her PhD thesis focused on 3D-structure determination and biophysical characterization of ssDNA virus capsids by X-ray crystallography and cryo-electron microscopy and 3D image reconstruction. She also worked extensively in identification, characterization, and structure-guided epitope mapping of novel antibodies against emerging pathogenic parvoviruses. She particularly worked on Bocavirus and Bufavirus, which cause respiratory and gastrointestinal infections in pediatric and immune-compromised patients worldwide. She received further training at the National Institutes of Health (NIH-NIDDK, USA) as a post-doc studying protein-DNA interactions using X-ray crystallography and worked toward characterizing DNA binding properties of novel CRISPR-Cas-like enzymes found in archaea. Most recently, she accepted a post-doctoral scientist position at Integrated Biotherapeutics, Inc. (USA) and is working on several projects pertaining to lethal, infectious diseases caused by multi-drug resistant staphylococcus aureus and hemorrhagic fever-causing viruses like Ebola and Marburg virus. Her projects involve a structure-guided approach towards rationally designing vaccine candidates that can potentially elicit broadly neutralizing antibodies against these antigens. Towards this end, she is involved in the structural design, production, biophysical, and functional characterization of the immunogen.
Dr. Shweta Kailasan Research Interests are Rational design of vaccine candidates based on a structure-guided approach for bacterial and viral infectious diseases and their characterization by in vitro and cell-based assays, as well as in vivo immunogenicity studies, Antibody discovery, characterization, and epitope mapping.