Dr. Umesh C. S. Yadav is an experienced scientist with expertise in biochemistry, cell and molecular biology, immunology and signal transduction mechanisms of inflammatory diseases including respiratory pathologies. He has extensive experience in the area of diabetes and cardiovascular complications, airway inflammation in both in-vitro and in-vivo models. Dr. Yadav has well documented record of productive research in the area of inflammatory pathogenesis. During his postdoctoral training he has identified that aldose reductase (AR) mediates inflammatory pathologies other than high glucose-induced diabetic complication such as bacterial endotoxin-induced inflammation. Further, his studies have focused mainly upon elucidating the mediation of inflammatory pathogenesis including allergic airway inflammation, metabolic disorder-induced diabetic complications and cardiovascular diseases. He has worked with a variety of human and animal cell-culture models including epithelial, vascular, hematopoietic, and immune cells and utilizing latest technologies.
To explore metabolic disorder-induced inflammatory pathologies including Diabetic complications, Cardiovascular diseases, Lung inflammation diseases such as asthma and COPD; The specific areas of interest include: (a) inflammation initiation and progression, (b) oxidative stress mechanisms, (c) Signaling mechanism in cell survival & cell-death, cell-differentiation and cell-migration, (d) angiogenesis, (e) cell-cycle regulation, and (e) immune modulation and regulation. My research is focused on identifying novel molecular targets and to discover anti-inflammatory small molecules and investigating scientific basis (mechanisms) for their preventive and therapeutic effects.