Abstract

To examine the effects of endophyte-infected tall fescue during late gestation on maternal and offspring performance, multiparous Angus cows (n = 40) were bred via AI and allocated into grazing treatments: toxic (E+) or nontoxic (E-) endophyte tall fescue. Cows body weight (BW), body temperature, body condition score (BCS), and respiration rate were recorded and blood samples collected on 180, 210 and 240 days of gestation. Calf’s BW were recorded at birth and weaning. Cow/calf pairs were managed as one group on nontoxic pasture from calving until weaning (180 days of age). Body weight decreased (P = 0.022) and body temperature increased (P < 0.0001) at day 240 in E+ compared to E- cows. BCS did not differ (P = 0.891) between treatments. Respiratory frequency increased (P = 0.003) in E+ compared to E- cows. Ergovaline concentration of urine increased (P = 0.003) at day 210 and 240 in E+ compared to E- cows. Prolactin concentrations decreased (P < 0.0001) at day 210 in E+ compared to E- cows. Birth and weaning weight decreased (P < 0.05) in calves from E+ cows compared to E- cows. Overall, grazing endophyte-infected tall fescue reduced maternal and subsequent offspring BW.

Keywords: Beef Cattle; Calf Development; Tall Fescue; Endophyte; Fescue Toxicity

References

1. De Battista J., et al. "Significance of endophyte toxicosis and current practices in dealing with the problem in South America”. Neotyphodium/Grass Interactions (1997): 383-388.
2. Young, Carolyn A., et al. "Characterization of Epichloë coenophiala within the US: are all tall fescue endophytes created equal?”. Frontiers in Chemistry 2 (2014): 95.
3. Hoveland Carl S. "Importance and economic significance of the Acremonium endophytes to performance of animals and grass plant”. Agriculture, Ecosystems and Environment 44.1-4 (1993): 3-12.
4. Thompson F N and JA Stuedemann. "Pathophysiology of fescue toxicosis”. Agriculture, Ecosystems and Environment 44.1-4 (1993): 263-281.
5. Burke JM., et al. "Reproductive responses to grazing endophyte-infected tall fescue by postpartum beef cows”. Theriogenology 56.2 (2001): 357-369.
6. Maria Edite Bezerra., et al. "Mycotoxins and their effects on human and animal health”. Food Control 36.1 (2014): 159-165.
7. Peters CW., et al. "Performance, forage utilization, and ergovaline consumption by beef cows grazing endophyte fungus-infected tall fescue, endophyte fungus-free tall fescue, or orchardgrass pastures”. Journal of Animal Science 70.5 (1992): 1550-1561.
8. Schultze AE., et al. "Alterations in bovine serum biochemistry profiles associated with prolonged consumption of endophyte-infected tall fescue”. Veterinary and Human Toxicology 41.3 (1999): 133-139.
9. Oliver JW., et al. "Alterations in hemograms and serum biochemical analytes of steers after prolonged consumption of endophyte-infected tall fescue”. Journal of Animal Science 78.4 (2000): 1029-1035.
10. Rhodes MT., et al. "Reduced blood flow to peripheral and core body tissues in sheep and cattle induced by endophyte-infected tall fescue”. Journal of Animal Science 69.5 (1991): 2033-2043.
11. Dyer, Donald C. "Evidence that ergovaline acts on serotonin receptors”. Life Sciences 53.14 (1993): PL223-PL228.
12. Oliver JW., et al. "Vasoconstriction in bovine vasculature induced by the tall fescue alkaloid lysergamide”. Journal of Animal Science 71.10 (1993): 2708-2713.
13. Oliver Jack W., et al. "Endophytic fungal toxin effect on adrenergic receptors in lateral saphenous veins (cranial branch) of cattle grazing tall fescue”. Journal of Animal Science 76.11 (1998): 2853-2856.
14. Klotz JL., et al. "Effects of selected combinations of tall fescue alkaloids on the vasoconstrictive capacity of fescue-naive bovine lateral saphenous veins”. Journal of Animal Science 86.4 (2008): 1021-1028.
15. Foote AP., et al. "Ergot alkaloids from endophyte-infected tall fescue decrease reticuloruminal epithelial blood flow and volatile fatty acid absorption from the washed reticulorumen”. Journal of Animal Science 91.11 (2013): 5366-5378.
16. Foote AP., et al. "Acute exposure to ergot alkaloids from endophyte-infected tall fescue does not alter absorptive or barrier function of the isolated bovine ruminal epithelium”. Animal 8.7 (2014): 1106-1112.
17. Association of Official Analytical Chemists. Official Methods of Analysis: Changes in Official Methods of Analysis Made at the Annual Meeting. Supplement. Volume 15. Association of Official Analytical Chemists (1990).
18. Van Soest., et al. "Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition”. Journal of Dairy Science 74.10 (1991): 3583-3597.
19. Beef Improvement Federation. “BIF Guidelines for Uniform Beef Improvement Programs”. Beef Improvement Federation, North Carolina State University (1986).
20. Quintans G., et al. "Effect of body condition and suckling restriction with and without presence of the calf on cow and calf performance”. Animal Production Science 50.10 (2010): 931-938.
21. Spoon RA and DM Hallford. "Growth response, endocrine profiles and reproductive performance of fine-wool ewe lambs treated with ovine prolactin before breeding”. Theriogenology 32.1 (1989): 45-53.
22. Wittrock JAM., et al. "Validation of a point-of-care glucometer for use in dairy cows”. Journal of Dairy Science 96.7 (2013): 4514-4518.
23. Hopkins AA., et al. "Agronomic performance and lamb health among several tall fescue novel endophyte combinations in the south-central USA”. Crop Science 50.4 (2010): 1552-1561.
24. Laven RA., and AR Peters. "Gross morphometry of the bovine placentome during gestation”. Reproduction in Domestic Animals 36.6 (2001): 289-296.
25. Schmidt SP and TG Osborn. "Effects of endophyte-infected tall fescue on animal performance”. Agriculture, Ecosystems and Environment 44.1-4 (1993): 233-262.
26. Cross Dee L. "Fescue toxicosis in horses”. Neotyphodium/Grass Interactions (1997): 289-309.
27. Fanning, M. D., et al. "A preliminary study of growth, serum prolactin and reproductive performance of beef heifers grazing Acremoniumcoenophialum-infected tall fescue”. Theriogenology 38.3 (1992): 375-384.
28. Watson, R. H., et al. "Productivity of cow–calf pairs grazing tall fescue pastures infected with either the wild-type endophyte or a nonergot alkaloid-producing endophyte strain, AR542”. Journal of Animal Science 82.11 (2004): 3388-3393.
29. Holloway JW and WT Butts. "Phenotype× nutritional environment interactions in forage intake and efficiency of Angus cows grazing fescue-legume or fescue pastures”. Journal of Animal Science 56.4 (1983): 960-971.
30. VI Ransom., et al. "Consumption of endophyte-infected fescue seed during the dry period does not decrease milk production in the following lactation”. Journal of Dairy Science 99.9 (2016): 7574-7589.
31. Brown MA. “Milk production in Angus, Brahman, and reciprocal-cross cows grazing common bermudagrass of endophyte-infected tall fescue”. Journal of Animal Science. 74.9 (1996): 2058-2066.
32. Seath DM., et al. "Grain feeding to milking cows at three levels as supplement to pasture”. Proceedings of 15^th international. Dairy Congress 1 (1959): 326-32.
33. Zbib N., et al. "Ergovaline in tall fescue and its effect on health, milk quality, biochemical parameters, oxidative status, and drug metabolizing enzymes of lactating ewes”. Journal of Animal Science 92.11 (2014): 5112-5123.
34. Karg H and D Schams. "Prolactin release in cattle”. Reproduction 39.2 (1974): 463-472.
35. Klotz James L. "Activities and effects of ergot alkaloids on livestock physiology and production”. Toxins 7.8 (2015): 2801-2821.
36. Klotz JL and KJ McDowell. "Tall fescue ergot alkaloids are vasoactive in equine vasculature”. Journal of Animal Science 95.11 (2017): 5151-5160.
37. Bolt DJ., et al. "Concentrations of PRL, LH, FSH, GH and TSH in plasma and pituitary of ewes grazing tall fescue and orchardgrass pastures”. Journal of Animal Science 55.1 (1982): 4.
38. Stidham WD., et al. "Toxic fescue linked to reduced milk output in ewes [Festuca, pasture grasses, Arkansas]”. Arkansas Farm Research (1982).
39. Lyons., et al. "Occurrence of peptide and clavine ergot alkaloids in tall fescue grass”. Science 232.4749 (1986): 487-489.
40. Monroe Juliette Lane., et al. "Effect of selenium and endophyte-contaminated fescue on performance and reproduction in mares”. Journal of Equine Veterinary Science 8.2 (1988): 148-153.
41. McCann JS., et al. "Hormonal and behavioral responses of gestating mares to low and highly infected tall fescue grass”. Equine Nutrition and Physiology Symposium (1989).
42. Belesky DP., et al. "Ergopeptine alkaloids in grazed tall fescue”. Agronomy journal 80.2 (1988): 209-212.
43. Ben-Jonathan., et al. "Dopamine as a prolactin (PRL) inhibitor”. Endocrine Reviews 22.6 (2001): 724-763.
44. Oliver JW and AE Schultze. "Histologic lesions in cattle fed toxic tall fescue grass”. Toxicologist 36 (1997): 46.
45. LeMaster CT., et al. "The effects of late gestation maternal nutrient restriction with or without protein supplementation on endocrine regulation of newborn and postnatal beef calves”. Theriogenology 87 (2017): 64-71.
46. Taylor MC., et al. "Toxicity in pregnant pony mares grazing Kentucky-31 fescue pastures”. Nutrition Reports International (1985).
47. Reynolds., et al. "Evidence for altered placental blood flow and vascularity in compromised pregnancies”. The Journal of Physiology 572.1 (2006): 51-58.
48. Vonnahme KA., et al. "Effect of early gestational undernutrition on angiogenic factor expression and vascularity in the bovine placentome”. Journal of Animal Science 85.10 (2007): 2464-2472.
49. Bolt DJ and J Bond. "Effects in pregnant beef heifers grazing fungus-infected tall fescue on birth weight, milk yield and calf growth”. Nutrition Reports International (1989).
50. Schmidt SP., et al. "Fescue fungus suppresses growth and reproduction in replacement beef heifers”. Highlights of agricultural research-Alabama Agricultural Experiment Station (USA) (1986).
51. Maresca Sebastian., et al. "Effect of protein restriction of bovine dams during late gestation on offspring postnatal growth, glucose-insulin metabolism and IGF-1 concentration”. Livestock Science 212 (2018): 120-126.
52. Varney DR., et al. "The effect of feeding tall fescue seed infected by Acremonium coenophialum on pregnancy and parturition in female rats”. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 89.2 (1988): 315-320.
53. Strickland James R., et al. "Board-invited review: St. Anthony's Fire in livestock: causes, mechanisms, and potential solutions”. Journal of Animal Science 89.5 (2011): 1603-1626.
54. Foote, A. P., et al. "Constriction of bovine vasculature caused by endophyte-infected tall fescue seed extract is similar to pure ergovaline”. Journal of Animal Science 90.5 (2012): 1603-1609.
55. Berde., et al. "Introduction to the pharmacology of ergot alkaloids and related compounds as a basis of their therapeutic application”. Ergot alkaloids and related compounds. Springer, Berlin, Heidelberg (1978): 1-28.
56. Klotz JL., et al. "Antagonism of lateral saphenous vein serotonin receptors from steers grazing endophyte-free, wild-type, or novel endophyte-infected tall fescue”. Journal of Animal Science 91.9 (2013): 4492-4500.
57. Vanhoutte Paul M. "Serotonin and the vascular wall”. International Journal of Cardiology 14.2 (1987): 189-203.
58. Foote AP., et al. "Ergot alkaloids decrease rumen epithelial blood flow”. Journal of Animal Science 90 (2012): 431-432.
59. Simko., et al. "Melatonin as a potential antihypertensive treatment”. Journal of Pineal Research 42.4 (2007): 319-322.
60. Goetsch AL., et al. "Intake, digestion, passage rate and serum prolactin in growing dairy steers fed endophyte-infected fescue with noninfected fescue, clover or wheat straw”. Journal of Animal Science 64.6 (1987): 1759-1768.
61. Parish JA., et al. "Use of nonergot alkaloid-producing endophytes for alleviating tall fescue toxicosis in stocker cattle”. Journal of Animal Science 81.11 (2003): 2856-2868.
62. Mote Ryan S., et al. "Metabolomics of fescue toxicosis in grazing beef steers”. Food and Chemical Toxicology 105 (2017): 285-299.
63. Clay and Keith. "Fungal endophytes of grasses: a defensive mutualism between plants and fungi”. Ecology 69.1 (1988): 10-16.
64. West and Charles P. "Physiology and drought tolerance of endophyte-infected grasses”. Biotechnology of Endophytic Fungi of Grasses (1994).