Research Article
Volume 7 Issue 5 - 2022
Natural Additives in Broilers: Stevia (Stevia Rebaudiana Bertoni) as an Innovator Growth Promotor
M Vaquero1, AJ 1, VN 2, AT Soltermann2, RD Miazzo1 and MF Peralta1*
1Unidad de Investigación Aviar, Producción Avícola, Facultad de Agronomia y Veterinaria, Universidad Nacional de Rio Cuarto-Rio Cuarto, Córdoba, Argentina
2Laboratorio de Vinculación Tecnológica, Facultad de Cs Exactas, Fisico-Quimicas y Naturales; Universidad Nacional de Rio Cuarto, Río Cuarto, Córdoba, Argentina
*Corresponding Author: MF Peralta, Unidad de Investigación Aviar, Producción Avícola, Facultad de Agronomia y Veterinaria, Universidad Nacional de Rio Cuarto-Rio Cuarto, Córdoba, Argentina.
Received: March 28, 2022; Published: April 26, 2022




Abstract

The aim was to evaluate Stevia (S) (0.5 - 2%) effects on productive parameters, primary immunological organs and gut health in broilers during fifteen days using S Mash (SM) on diets. Twenty-five male, 1-day old Ross broiler were used for first day old chicken were divided in: Treatment 1 (T1) (without S), T2: T1 + SM (0.5%), T3: T1 + SM (1%) and T4: T1 + SM (2%). Each group had five broilers/five repetitions/treatment. At the end of assay, immediately following death, all broilers were dissected, Thymus, Fabricius Bursa and Gut were removed and process for histopathological and histomorphometric study. In gut was measured Villi Height/Crypt Deep (VH/CD) Ratio. Also, it was determinate Conversion Index (CI). The data were analysed by ANOVA and posteriorly test. Results: HV/CD Ratio was T1‹T3‹T4‹T2 (p ≤ 0.01). On gut were noticed enhanced plasmatic and goblet cells number and mucus layer on T2, T3 and T4. Thymus and Fabricius Bursa showed early inmunologic maturity in all groups receive S. CI was similar between the different treatment (no significative). In conclusion: Stevia (0.5 - 2% SM) produce early immunologic maturity on primary immune organ and partially increasing intestinal functionality, mainly when S is administered at 2%, in broilers during the first fifteen days old.

 

Keywords: Chicken; Gut Heath; Intestinal Functionality; Natural Growth Promotor; Productive Parameters

References

  1. Atteh JO., et al. “Evaluation of supplementary stevia (Stevia rebaudiana, Bertoni) leaves and stevioside in broiler diets: effects on feed intake, nutrient metabolism, blood parameters, and growth performance”. Journal of Animal Physiology and Animal Nutrition6 (2008): 640-649.
  2. Aviagen Group. Broiler Ross 308: Objetivos de rendimiento (2012).
  3. Awad A., et al. “Effects of dietary inclusion of probiotic and synbiotic on growth performance, organ weights, and intestinal histomorphology of broiler chickens”. Poultry Science 88 (2009): 49-55.
  4. Celi P., et al. “Biomarkers of gastrointestinal functionality in animal nutrition and health”. Animal Feed Science Technology 250 (2019): 9-31.
  5. Chen J., et al. “Identification of potential biomarkers for gut barrier failure in broiler chickens”. Frontiers in Veterinary Science 2 (2015): 14-24.
  6. Christaki E., et al. “Stevia rebaudianaas a novel source of food additives”. Journal of Food and Nutrition Research 4 (2013): 195-202.
  7. Daneshyar M., et al. “Evaluation of dietary stevioside supplementation on anti-human serum albumin immunoglobulin G, Alpha-1-glycoprotein, body weight and thyroid hormones in broiler chickens”. Journal of Animal Physiology and Animal Nutrition4 (2011): 627-633.
  8. Di Rienzo JA., et al. “Grupo InfoStat, FCA”. Universidad Nacional de Córdoba, Argentina (2016).
  9. Grashorn MA. “Use of phytobiotics in broiler nutrition –an alternative to infeed antibiotics?” Journal of Animal and Feed Sciences3 (2010): 338-347.
  10. Grosso V., et al. “Stevia Rebaudiana Bertoni. Cuadernillo de Divulgacion del Laboratorio de Desarrollo y Vinculacion Tecnologica”. UniRio Editora (2012): 24.
  11. Huyghebaert G., et al. “An update on alternatives to antimicrobial growth promoters for broilers”. The Veterinary Journal2 (2011): 182-188.
  12. Jingle J., et al. “Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens”. Poultry Science 99 (2020): 3948-3958.
  13. Kim W and Lillehoj H. “Immunity, immunomodulation, and antibiotic alternatives to maximize the genetic potential of poultry for growth and disease response”. Animal Feed Science and Technology 250 (2019): 41-50.
  14. Kogut M. “The effect of microbiome modulation on the intestinal health in poultry”. Animal Feed Science and Technology 250 (2019): 32-40.
  15. Lemus Mondanca R., et al. “Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects”. Food Chemistry 132 (2012): 1121-1132.
  16. Molina-Barrios RM., et al. “Effect of dietary stevia-based sweetener on body weight and humoral immune response of broiler chickens”. Veterinary World4 (2021): 913-917.
  17. Murugesan GR., et al. “Phytogenic feed additives as an alternative to antibiotic growth promoters in broiler chickens”. Frontiers of Veterinary Sciences 2 (2015): 21.
  18. Olfert ED., et al. “Guide to the Care and Use of Experimental Animals”. 2nd Edition, Canadian Council on Animal Care, Ottawa (1993).
  19. Peralta MF., et al. “Rediscovering the importance of mucosal immune system (MIS) in poultry”. Academia Journal of Biotechnology3 (2016): 91-95.
  20. Peralta MF., et al. “Gut-associated lymphoid tissue: a key tissue inside the mucosal immune system of hens immunized with Escherichia coli F4”. Frontiers of Immunology 8 (2017): 568.
  21. Peralta MF., et al. “Stevia (Stevia rebaudiana Bertoni): un nuevo aditivo natural en avicultura?” Revista de Ciencias Veterinarias1 (2018a): 7-19.
  22. Peralta MF., et al. “Effects of Saccharomyces cerevisiae Association with Threonine on Productive performance in broilers”. Iranian Journal of Applied Animal Science4 (2018b): 677-684.
  23. Peralta MF., et al. “Nutrición aviar: alternativas naturales para optimizar la funcionalidad gastrointestinal”. Revista Científica FAV-UNRC Ab Intus2 (2019): 103-109.
  24. Peralta MF., et al. “STEVIA (Stevia Rebaudiana Bertoni) Extract: A Natural Alternative in Broilers Nutrition”. Applied Science and Innovative Research4 (2020): 38-49.
  25. Pirgozliev V., et al. “Feeding dry stevia leaf (Stevia rebaudiana) or xylanase improves the hepatic antioxidative status of broiler chickens”. Research in Veterinary Science 136 (2021): 227-229.
  26. Quesada-Figueroa J. “Utilización de tres niveles de stevia rebaudiana en alimentación de broilers y su influencia en flora y desarrollo intestinal”. Tesis para obtener el titulo de Ingeniero Agrónomo. Salgolqui, Ecuador (2011): 102.
  27. Rostagno HS. “Cap. 2: Exigencias nutricionais das Aves”. En: Tabelas brasileiras para Aves e suinos. 4th Edition (2017): 259-398.
Citation: MF Peralta., et al. “Natural Additives in Broilers: Stevia (Stevia Rebaudiana Bertoni) as an Innovator Growth Promotor”. EC Veterinary Science 7.5 (2022): 20-28.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


July Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the July issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before July 19, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.