Research Article
Volume 7 Issue 4 - 2022
Pharmacokinetics of Marbofloxacin in Dogs After Single Intravenous and Oral Administration, and its Interaction with Sucralfate
Errecalde C1*, Urzúa N3, Messina MJ1, Caverzan M1, Prieto G1, Luders C2
1Universidad Nacional de Río Cuarto, Argentina
2Universidad Católica de Temuco, Chile
3Universidad Santo Tomás, Filial Puerto Montt, Chile
*Corresponding Author: Errecalde C, Farmacología, Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Río Cuarto, Argentina.
Received: January 31, 2022; Published: March 30, 2022




Abstract

The study aims to establish plasma pharmacokinetic parameters of marbofloxacin in dogs, at a 2 mg/kg single dose, intravenously, orally only and orally with sucralfate pre-treatment (1g per animal), to evaluate its influence on antimicrobial absorption. Concentrations of marbofloxacin in plasma were determined using high-performance liquid chromatography (HPLC) with fluorescence detection. After intravenous application of marbofloxacin, the mean (± SD) of AUC0-24, Vd, Clt and MRT, were 13.5 ± 3.4 μg-h/mL, 2.45 ± 0.9 L/kg, 157.3 ± 47.9 mL/h/kg and 14.6 ± 1.3 hours, respectively. After oral administration, the Cmáx, t½ abs and bioavailability were 1.1 ± 0.5 μg/mL, 0.5 ± 0.3 hours and 107.5 ± 11.7%, respectively. In animals given an oral dose of marbofloxacin with sucralfate pre-treatment, delay absorption and there was a significant decrease in Cmax (< 53.5 ± 18.6%) and AUC (< 42.6 ± 10.7%).

Keywords: Marbofloxacin; Dog; Pharmacokinetic

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Citation: Errecalde C., et al. ““Pharmacokinetics of Marbofloxacin in Dogs After Single Intravenous and Oral Administration, and its Interaction with Sucralfate”. EC Veterinary Science 7.4 (2022): 35-40.

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