Research Article
Volume 5 Issue 12 - 2020
The Use of Single Dose Dependent Evaluation of Rabbit Pasteurellosis Vaccines in Comparison with Booster Dose Evaluation Assay in Mice
Fatma Mohammed Gadallah1, Eman M Soliman1 and El-Sayed E I2*
1Central Laboratory for Evaluation of Veterinary Biologics, Abbasia, Agriculture Research Center (CLEVB/ARC), Cairo, Egypt
2Veterinary Serum and Vaccines Research Institute, Abbasia, Agriculture research center (VSVRI/ARC), Cairo, Egypt
*Corresponding Author: El-Sayed E I, Veterinary Serum and Vaccines Research Institute, Abbasia, Agriculture research center (VSVRI/ARC), Cairo, Egypt.
Received: November 17, 2020; Published: November 30, 2020


Pasteurellosis is one of the highly contagious bacterial diseases of rabbits caused by P. multocida and causes considerable economic loss in large production units throughout the world. Consequently, investigation on the development of effective control and preventive methods are of a vital importance. Therefore it is important to achieve a good vaccine with a good vaccination assay. This work aimed to evaluate the protective effect of a single dose vaccination assay in comparison with booster dose vaccination assay in routine use against pasteurellosis in commercial rabbits. A total of 17 different inactivated formalized used in this study and other 17 oil adjuvent rabbit pasteurellosis vaccine batches, produced by VSVRI were tested by protection mean of vaccination challenge assay method using virulent P. multocida strains. The protection mean value of the satisfactory vaccine batches of formalized rabbit pasteurellosis vaccines, was 0.91 log difference between the vaccinated and unvaccinated mice in the single dose assay compared with 2.05 log in the booster dose assay. Meanwhile the unsatisfactory batches it was 0.49 log in the single dose assay compared with 1.08 log in the booster dose assay. Regarding to the satisfactory vaccine batches of oil adjuvant rabbit pasteurellosis vaccines it was 0.93 log in the single dose assay compared with 2.11 log in the booster dose assay. Meanwhile it was 0.52 log in the single dose assay compared with 1.18 log in the booster dose assay in unsatisfactory vaccine batches. Findings of this study proved that the minimum requirement of protection associated with single dose vaccination assay may recommend these finding to be used in the evaluation of rabbit Pasteurellosis vaccine protocols.

Keywords: Rabbit Pasteurellosis; P Multocida


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Citation: El-Sayed E I., et al. “The Use of Single Dose Dependent Evaluation of Rabbit Pasteurellosis Vaccines in Comparison with Booster Dose Evaluation Assay in Mice”. EC Veterinary Science 5.12 (2020): 76-83.

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