Review Article
Volume 5 Issue 11 - 2020
Coronavirus (SARS-CoV-2): Molecular Mechanism of Coronavirus and Therapeutic Approaches (Stem Cell Therapy and Vaccine) for the Treatment of COVID-19
Lalit M Jeena1*, Dinesh Kumar2, Renu Tanwar1, Arpit Saxena3, Sabita Chourasia4 and Bhupender Patuna1
1Department of IVF and Reproductive Biology Centre, Maulana Azad Medical College, New Delhi, India
2Department of Anatomy, Maulana Azad Medical College, New Delhi, India
3Research and Development, Hester Biosciences Ltd, Ahmedabad, India
4Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
*Corresponding Author: Lalit M Jeena, Department of IVF and Reproductive Biology Centre, Maulana Azad Medical College, New Delhi, India.
Received: August 20, 2020; Published: October 31, 2020




Abstract

Coronavirus or SARS-CoV-2 is the causative agent of the pandemic viral pneumonia disease COVID-19, identified in the late 2019. It is said to have originated in Wuhan, China and has now spread throughout the world and is a global pandemic. SARS-CoV-2 belongs to β-coronavirus family and has an identical genomic structure to bat coronavirus. SARS-CoV-2 mediates the entry in to host cell through host angiotensin-converting enzyme 2 (ACE 2). SARS-CoV-2 S protein has higher affinity to ACE2 receptor and mainly spreads the infection in the respiratory tract. The specific drugs/vaccine or any therapeutics approaches are required to prevent the current pandemic. Unfortunately, till date, there is no specific vaccine or therapeutic which is available to control the disease. Research efforts for development of COVID-19 pandemic are unprecedented in terms of promising time period. In this regard, we conducted a review on SARS-CoV-2 to cover the molecular mechanism to improve and increase understanding of the virus and therapeutic approaches such as vaccine and mesenchymal stem cell therapy (MSCs), which may provide the basis of future management of COVID-19.

Keywords: SARS-CoV-2; Angiotensin-Converting Enzyme 2 (ACE 2); Interferons and MSCs

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Citation: Lalit M Jeena., et al. “Coronavirus (SARS-CoV-2): Molecular Mechanism of Coronavirus and Therapeutic Approaches (Stem Cell Therapy and Vaccine) for the Treatment of COVID-19”. EC Veterinary Science 5.11 (2020): 84-94.

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