Research Article
Volume 5 Issue 8 - 2020
Serum Cardiac Troponin I Concentrations in Cats with Lower Respiratory Diseases
Seyed Reza Ghiassi1*, Amir Momtaheni2, Majid Mohammad Sadegh3 and Maneli Ansari4
1Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Branch of Garmsar, Garmsar, Iran
2Doctor of Veterinary Medicine (DVM), Pulse Pet Clinic, Tehran, Iran
3Associate Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Branch of Garmsar, Garmsar, Iran
4Doctor of Veterinary Medicine, Board Certified Small Animal Internist, Iranian Pet Hospital, Tehran, Iran
*Corresponding Author: Seyed Reza Ghiassi, Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Branch of Garmsar, Garmsar, Iran.
Received: June 11, 2020; Published: July 10,2020


Objectives: Determination of serum cardiac troponin I (cTnI) levels in cats with lower respiratory diseases (LRDs) and evaluation of clinical variables associated with increased serum cTnI concentrations in cats with LRDs.

Materials and Methods: 46 cats. Serum cTnI concentrations were measured in 23 cats with LRDs and compared with 23 healthy normal cats..

Results: Sixty-nine percent of cats (16 of 23) with LRDs had elevated cTnI levels (cTnI > 0.16 ng/mL). The mean and range of plasma cTnI in cats with LRDs were significantly (P < 0.001) greater than healthy control cats. There was no correlation between respiratory signs, type of LRDs, and radiographic patterns of LRDs with plasma cTnI concentrations in cats with LRDs.

Conclusion: Serum cardiac troponin I concentration was significantly increased in cats suffering from LRDs when compared to control group. Measurement of cTnI levels in cats could not be used as a stand-alone test to differentiate LRDs from cardiac disease in cats.

Keywords:Cardiac Diseases; Cardiac Biomarkers; Feline


  1. Langhorn R and Willesen JL. “Cardiac Troponins in Dogs and Cats”. Journal of Veterinary Internal Medicine 29 (2015): 164-170.
  2. Sleeper MM., et al. “Cardiac troponin I in the normal dog and cat”. Journal of Veterinary Internal Medicine 15 (2001): 501-503.
  3. Oyama MA and Solter PF. “Validation of a commercially available human immunoassay (AccuTnI, Beckman Coulter, Inc.) for the measurement of canine cardiac troponin-I”. Journal of Veterinary Cardiology 6 (2004): 17-24.
  4. Adin DB., et al. “Comparison of canine cardiac troponin I concentrations as determined by 3 analyzers”. Journal of Veterinary Internal Medicine 20 (2006): 1136-1142.
  5. Akwe J., et al. “A Review of Cardiac and Non-Cardiac Causes of Troponin Elevation and Clinical Relevance Part II Non Cardiac Causes”. Journal of Cardiology and Current Research 11.1 (2018): 00364.
  6. Hori Y., et al. “Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy”. Journal of Veterinary Internal Medicine 32 (2018): 922-929.
  7. Borgeat K., et al. “Plasma cardiac troponin I concentration and cardiac death in cats with hypertrophic cardiomyopathy”. Journal of Veterinary Internal Medicine 28 (2014): 1731-1737.
  8. Fox PR. “Feline cardiomyopathies”. In: Fox PR, Sisson D, Moise NS, eds. Canine and feline cardiology. 2nd edition. Philadelphia, Pa: WB Saunders (1999): 621-678.
  9. Porciello F., et al. “Cardiac troponin I is elevated in dogs and cats with azotaemia renal failure and in dogs with non-cardiac systemic disease”. Australian Veterinary Journal 86 (2008): 390-394.
  10. Langhorn R., et al. “Cardiac Troponin I and T as Prognostic Markers in Cats with Hypertrophic Cardiomyopathy”. Journal of Veterinary Internal Medicine 28 (2014): 1485-1491.
  11. Mehta NJ., et al. “Clinical Usefulness and Prognostic Value of Elevated Cardiac Troponin I Levels in Acute Pulmonary Embolism”. American Heart Journal 145 (2003): 821-825.
  12. Mikulewicz M and Lewczuk J. “Importance of cardiac biomarkers in risk stratification in acute pulmonary embolism”. Cardiology Journal 15 (2008): 17-20.
  13. García-laorden MI., et al. “Biomarkers for the Acute Respiratory Distress Syndrome: How to Make the Diagnosis More Precise”. Annals of Translational Medicine 5.14 (2017): 283.
  14. Giannitsis E., et al. “Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism”. Circulation 102 (2000): 211-217.
  15. Wright RS., et al. “Elevations of cardiac troponin I are associated with increased short-term mortality in noncardiac critically ill emergency department patients”. The American Journal of Cardiology 90.6 (2002): 634-636.
  16. Herndon WE., et al. “Cardiac troponin I in feline hypertrophic cardiomyopathy”. Journal of Veterinary Internal Medicine 16 (2002): 558-564.
  17. Herndon WE., et al. “Assessment of plasma cardiac troponin I concentration as a means to differentiate cardiac and noncardiac causes of dyspnea in cats”. American Veterinary Medical Association 233 (2008): 1261-1264.
  18. Wells SM., et al. “Evaluation of blood cardiac troponin I concentrations obtained with a cage-side analyzer to differentiate cats with cardiac and noncardiac causes of dyspnea”. Journal of the American Veterinary Medical Association 244 (2014): 425-430.
  19. Connolly DJ., et al. “Assessment of the diagnostic accuracy of circulating cardiac troponin I concentration to distinguish between cats with cardiac and non-cardiac causes of respiratory distress”. Journal of Veterinary Cardiology 11 (2009): 71-78.
  20. Prosek R., et al. “Distinguishing cardiac and noncardiac dyspnea in 48 dogs using plasma atrial natriuretic factor, B-type natriuretic factor, endo- thelin, and cardiac troponin-I”. Journal of Veterinary Internal Medicine 21 (2007): 238-242.
  21. Connolly DJ., et al. “Circulating natriuretic peptides in cats with heart disease”. Journal of Veterinary Internal Medicine 22 (2008): 96-105.
  22. Harrison A and Amundson S. “Evaluation and management of the acutely dyspnoeic patient: the role of biomarkers”. American Journal of Emergency Medicine 23 (2005): 371-378.
Citation: Seyed Reza Ghiassi., et al. “Serum Cardiac Troponin I Concentrations in Cats with Lower Respiratory Diseases”. EC Veterinary Science 5.8 (2020): 48-55.

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