Mini Review
Volume 5 Issue 8 - 2020
Cytology and Other Diagnostic Tools in Urothelial Carcinoma
Javier Martínez-Caro*
Faculty of Veterinary Medicine, University of Santiago de Compostela, Spain
*Corresponding Author: Javier Martínez-Caro, Faculty of Veterinary Medicine, University of Santiago de Compostela, Lugo, Spain.
Received: April 15, 2020; Published: July 30, 2020




Abstract

Urothelial carcinoma also known as transitional cell carcinoma, is the most frequent neoplasm affecting urinary bladder. It can also arise in urethra, prostate or vagina. Clinical signs are usually nonspecific and are similar to other processes affecting the lower urinary tract, like cystitis, urolithiasis or lower urinary tract infection. Diagnostic approach includes a minimum database (complete blood count, serum chemistry and urinalysis) and more specific test, like urinary culture and sensitivity, imaging of the lower urinary tract, cytology, histopathology and/or molecular tests (i.e. detection of BRAF mutation).

On cytology, we can detect epithelial cells, with basophilic cytoplasm, typically showing abundant criteria of malignancy, such as anisokaryosis, anisonucleoliosis, and increase in nuclear-to-cytoplasmic ratio. The presence of eosinophilic cytoplasmic inclusions also called Melamed-Wolinska bodies may be a diagnostic clue and give some more support on urothelial carcinoma diagnosis.

Keywords:Urothelial Carcinoma; Transitional Cell Carcinoma; Cytology; Melamed-Wolinska Bodies

References

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Citation: Javier Martínez-Caro.“Cytology and Other Diagnostic Tools in Urothelial Carcinoma”. EC Veterinary Science 5.8 (2020): 11-18.

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