Review Article
Volume 8 Issue 2 - 2020
Pharmacological Management of Obesity
Mohamad Mohsen Motawea1*, Halima Mohammed Saeed M Al-Jadaani2, Abdullah Ahmed Almayouf3, Reham Abdulaziz Altaifi2, Mohammed Abdullah Al Ghazal4, Kholoud Khaled Momenah5, Nasser Mohammed Y Alamri6, Mohammed Sami Basubrain7, Ghadi Abdulaziz Jastaniah7, Lama Rashid Elessawi8 and Abdullah Musaad Alahmadi9
1Abdul Latif Jameel Hospital for Medical Rehabilitation, Saudi Arabia
2Batterjee Medical College, Saudi Arabia
3King Faisal University, Saudi Arabia
4King Fahad Hospital, Saudi Arabia
5Administration of Home Health Care, Saudi Arabia
6Alyarmook West Primary Health Center, Saudi Arabia
7Ibn Sina National College for Medical Studies, Saudi Arabia
8Albalad Primary Healtg Care, Saudi Arabia
9Madinah General Hospital, Saudi Arabia
*Corresponding Author: Mohamad Mohsen Motawea, Abdul Latif Jameel Hospital for Medical Rehabilitation, Saudi Arabia.
Received: January 03, 2020; Published: January 22, 2020


Introduction: A major pandemic of the 21st-century obesity is in both developed and developing countries, which is increasingly contributing to chronic diseases associated with it and draining economic resources. Despite the overwhelming amount of information regarding obesity and the morbidity and mortality associated with it, the number of obese individuals rise each year. The dangers of being obese are far more alarming than most people realize. Obesity significantly increases the risk of diabetes mellitus, hypertension, coronary artery disease, dyslipidaemia, stroke, gallbladder disease, osteoarthritis, gastroesophageal reflux disease, sleep apnoea, lower back pain, asthma. Obesity is also known to increase the risk of cancers of colon, endometrium, prostate, and breast. Using pharmacotherapy for weight management is consistent in treating obesity as a chronic disease that requires a multifaceted approach, including behavioral intervention, medical intervention, and dietary change. The current guideline recommends that a person who fails to respond to lifestyle intervention with BMI more than 30 kg/m2 with obesity-related comorbidity should opt for weight loss medical treatment.

Aim of the Study: Aim of study is to understand pharmacological intervention of weight loss management.

Methodology: The review is comprehensive research of PUBMED from the year 1998 to 2017. 

Conclusion: The benefits of weight reductions are irrefutable, and lifestyle intervention aimed at promoting weight loss remains the cornerstone of the treatment. But despite all most patients are unable to achieve 10kg weight loss targets and maintenance. Thus, pharmacotherapy is one valuable option in weight loss management with growing acceptance to it. Several drugs are approved and currently used, but long-term data on safety and efficacy in cardiovascular conditions remain warranted. Apart from this the health care practitioners should consider the weight effects of pharmacotherapy in management of obesity-related comorbidities with the use of weight-neutral or weight-reducing medication that can complement patient’s desire and for healthier lifestyles.

Keywords: Weight Loss Management; Pharmacotherapy


  1. Kumar RB and Aronne LJ. “Pharmacologic treatment of obesity”. In Endotext (2017).
  2. James WP., et al. “Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects”. New England Journal of Medicine 363.10 (2010): 905-917.
  3. World Health Organization. “Obesity: preventing and managing the global epidemic”. World Health Organization (2000).
  4. Williams Gareth. "Orlistat over the counter" (2007): 1163-1164.
  5. Rossner S., et al. “Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity”. Obesity Research (2000).
  6. Sjöström L., et al. “Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients”. Lancet 352.9123 (1998): 167-172.
  7. Hollander PA., et al. “Role of orlistat in the treatment of obese patients with type 2 diabetes: a 1-year randomized double-blind study”. Diabetes Care 21.8 (1998): 1288-1294.
  8. Cavaliere H., et al. “Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid)”. International Journal of Obesity 25.7 (2001): 1095.
  9. Nelson DL and Gehlert DR. “Central nervous system biogenic amine targets for control of appetite and energy expenditure”. Endocrine 29.1 (2006): 49-60.
  10. Wilding J., et al. “A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects”. International Journal of Obesity 28.11 (2004): 1399.
  11. Allison DB., et al. “Controlled‐release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)”. Obesity 20.2 (2012): 330-342.
  12. Gadde KM., et al. “Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial”. The Lancet 377.9774 (2011): 1341-1352.
  13. Fujioka K. “Safety and tolerability of medications approved for chronic weight management”. Obesity 23 (2015): S7.
  14. Thomsen WJ., et al. “A novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization”. Journal of Pharmacology and Experimental Therapeutics 325.2 (2008): 577-587.
  15. Xu Y., et al. “5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis”. Neuron 60.4 (2008): 582-589.
  16. Smith SR., et al. “Multicenter, placebo-controlled trial of lorcaserin for weight management”. New England Journal of Medicine 363.3 (2010): 245-256.
  17. Greenway FL., et al. “Rational design of a combination medication for the treatment of obesity”. Obesity 17.1 (2009): 30-39.
  18. Wadden TA., et al. “Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR‐BMOD trial”. Obesity 19.1 (2011): 110-120.
  19. Hollander P., et al. “Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes”. Diabetes Care 36.12 (2013): 4022-4029.
  20. Van Can J., et al. “Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults”. International Journal of Obesity 38.6 (2014): 784.
  21. Steinberg WM., et al. “Impact of liraglutide on amylase, lipase, and acute pancreatitis in participants with overweight/obesity and normoglycemia, prediabetes, or type 2 diabetes: secondary analyses of pooled data from the SCALE clinical development program”. Diabetes Care 40.7 (2017): 839-848.
  22. Davies MJ., et al. “Efficacy of liraglutide for weight loss among patients with type 2 diabetes: the SCALE diabetes randomized clinical trial”. Journal of the American Medical Association 314.7 (2015): 6876-6899.
  23. Erlanger SR and Henson EA. “Classification and pharmacological management of obesity”. Pharmacy and Therapeutics 33.12 (2008): 724.
Citation: Mohamad Mohsen Motawea., et al. “Pharmacological Management of Obesity”. EC Pharmacology and Toxicology 8.2 (2020): 01-06.

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