Research Article
Volume 10 Issue 9 - 2022
Cardioprotective Effect of -(4'-Methoxyphenyl)-6,7- Dimethoxy-1,2,3,4-Tetrahydroisoquinoline
Sadriddin N Boboev1, Inoyat Z Jumayev1*, Pulat B Usmanov1 and Sherzod N Zhurakulov2
1Institute of Biophysics and Biochemistry of National University of Uzbekistan, Uzbekistan
2Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent, Uzbekistan
*Corresponding Author: Inoyat Z Jumayev, Institute of Biophysics and Biochemistry of National University of Uzbekistan, Uzbekistan.
Received: August 22, 2022; Published: August 30, 2022




Abstract

In studies, 1-(4'-methoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-4) and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-36) cardioprotective properties of alkaloids were studied. In this case, cardiomyocyte Ca2+-transport systems in the presence of their specific inhibitors were carried out under hypoxia conditions. Blockers of potential-dependent Ca2+-channels, such as nifedipine and Na+/Ca2+- exchange blockers such as NiCl2 were used. The purpose of this study is to evaluate the cardioprotective properties of F-4 and F-36 isoquinoline alkaloids under hypoxia conditions in vitro and to expand the understanding of hypoxiarelated molecular signaling pathways.

Keywords: Papillary Muscle; Ca-Channels; Na+/Ca2+- Exchange; Hypoxia

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Citation: Inoyat Z Jumayev., et al. “Cardioprotective Effect of -(4'-Methoxyphenyl)-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline”. EC Pharmacology and Toxicology 10.9 (2022): 15-20.

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