Research Article
Volume 10 Issue 8 - 2022
Piper nigrum Mitigates Reserpine-Induced Orofacial Dyskinesia in Wistar Rats
Rupali Arun Patil1*, Shubhangi Pawar2 and Sandeep D Sadafal2
1Department of Pharmacology, Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education and Research, Nasik, Maharashtra, India
2Department of Pharmacology, MGV’s Pharmacy College, Panchavati, Nasik, Maharashtra, India
*Corresponding Author: Rupali Arun Patil, Department of Pharmacology, Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education and Research, Nasik, Maharashtra, India.
Received: June 17, 2022; Published: July 27, 2022


Piper nigrum is well known for antioxidant activity. Neurodegenerative disorders including Parkinsonism involve oxidative stress as major cause. Existing study was conducted to explore effect of ethanolic extract of P. nigrum (PN) fruits on orofacial dyskinesia induced by reserpine in Wistar rats. Body weight, behavioural and biochemical parameters were evaluated. PN significantly reversed parameters of reserpine induced orofacial dyskinesia including vacuous chewing movements, tongue protrusions and orofacial bursts. PN reversed cognitive impairment induced by reserpine assessed using elevated plus maze and locomotion assessed using open field apparatus. PN also reversed levels of anti-oxidant enzymesviz superoxide dismutase, catalase, glutathione reductase and extent of lipid peroxidation and exhibited protective effect against oxidative damage induced by reserpine.

Keywords: Neurodegeneration, Oxidative Stress, Piper nigrum, Reserpine


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Citation: Rupali Arun Patil., et al. “Piper nigrum Mitigates Reserpine-Induced Orofacial Dyskinesia in Wistar Rats”. EC Pharmacology and Toxicology 10.8 (2022): 01-13.

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