Short Communication
Volume 10 Issue 7 - 2022
Phosphodiesterases: Biological Activities of Chemical Compounds that Antagonize these Enzymes
Chika J Mbah*
Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
*Corresponding Author: Chika J Mbah, Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
Received: May 25, 2022; Published: June 30, 2022


Phosphodiesterases (PDEs) are enzymes whose primary function is to terminate signaling of cyclic nucleotides by catalyzing the hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) respectively. Invariably, these enzymes are considered to be critical regulators of the intracellular concentrations of cAMP and cGMP including their signaling pathways and accompanied biological effects. The levels of these cyclic nucleotides are maintained through a balance between production (done by adenyl cyclase and guanyl cyclase from adenosine triphosphate and guanosine triphosphate, respectively) and breakdown, (carried out by phosphodiesterases) resulting in the formation of the inactive forms 5’AMP and 5’GMP respectively. A number of extracellular stimuli, namely cytokines, light, growth factors, neurotransmitters and peptide hormones are generators of these signals to be carried by cyclic nucleotides. Cyclic nucleotides (signal-transducing molecules) modulate a number of biological processes, including apoptosis, myocardial contractility, platelet aggregation, proliferation and vascular smooth muscle relaxation. Various therapeutic agents block the unique phosphodiesterases function by increasing cyclic nucleotide concentration levels. In the present article, general information of phosphodiesterases will be given as well as presentation of a number of chemical compounds that target these enzymes.

Keywords: Phosphodiesterases; Phosphodiesterases Antagonists; Biological Activities


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Citation: Chika J Mbah. “Phosphodiesterases: Biological Activities of Chemical Compounds that Antagonize these Enzymes”. EC Pharmacology and Toxicology 10.7 (2022): 64-68.

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