Research Article
Volume 9 Issue 3 - 2021
Evaluation of Syringic Acid and Sinapic Acid in Chronic Constriction Injury Induced Neuropathy
Shubhangi H Pawar1*, Aman Upaganlawar2 and Chandrashekhar Upasani2
1Department of Pharmacology, MGV’s Pharmacy College, Nashik, Maharashtra, India
2Department of Pharmacology, SNJB’s SSDJ College of Pharmacy, Chandwad, Maharashtra, India
*Corresponding Author: Shubhangi H Pawar, Department of Pharmacology, MGV’s Pharmacy College, Nashik, Maharashtra, India.
Received: January 14, 2021; Published: February 27, 2021




Abstract

Objective: As oxidative stress is a key contributor in neuropathy, natural antioxidants may be helpful in its treatment. Syringic acid and Sinapic acid are polyphenols with proven antioxidant, anti-inflammatory activity. So, this study designed to evaluate effect of Syringic acid and Sinapic acid in chronic constriction injury (CCI) induced neuropathy.

Method: Wistar rats divided into ten groups. CCI surgery performed by method of Bennett and Xie and animals treated with Syringic acid 12.5, 25, 50 mg/kg/day, Sinapic acid 5, 10, 20 mg/kg/day and gabapentin 300 mg/kg/day orally for 5 weeks. Heat hyperalgesia, cold allodynia, mechanical allodynia and mechanical hyperalgesia assessed weekly. At the end of treatment motor nerve conduction velocity measured. Blood sample collected under light anaesthesia for biochemical and cytokines estimations (electrolytes, C-reactive proteins, TNF-α, IL-6) and sciatic nerve isolated after sacrification for antioxidant (MDA, GSH, SOD, NO) and histological study.

Result: 5 weeks treatment with Syringic acid and Sinapic acid decreased allodynia and hyperalgesic response significantly with p < 0.01**. Nerve conduction velocity increased significantly in dose dependant manner (p < 0.05*, p < 0.01**). We found dose dependant and significant reversal of alterations in markers of oxidative stress, antioxidants, electrolytes and cytokines with p < 0.05* and p < 0.01**. Histopathological damage in neuronal tissue is protected by treatment with Syringic and Sinapic acid.

Conclusion: Syringic acid and Sinapic acid have shown neuroprotective effect which may be attributed to its anti-hyperalgesic, antioxidant and anti-inflammatory action.

Keywords : Neuropathy; CCI; Phenolic Acids; MNCV; Neuroprotective

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Citation: Shubhangi H Pawar., et al. “Evaluation of Syringic Acid and Sinapic Acid in Chronic Constriction Injury Induced Neuropathy”. EC Pharmacology and Toxicology 9.3 (2021): 32-34.

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