Letter to Editor
Volume 9 Issue 3 - 2021
Vitamin C Against Ncov-19 Infection: A Hope in the Pandemic COVID-19
Muhammad Torequl Islam*
Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh
*Corresponding Author: Muhammad Torequl Islam, Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
Received: April 23, 2020; Published: February 26, 2021




Dear Editor

Vitamin C (also called ascorbic acid, AA), an essential micronutrient for humans [1]. Deficiency of this vitamin results in impaired immunity [2] and higher susceptibility to infections [3]. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes [1]. It contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system [2]. It supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity in our body [3]. It accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing [1]. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage [4]. Moreover, it has many important roles in our skin health [5]. It enhances the differentiation and proliferation of B- and T-cells, due to its ability of gene regulating effects [6]. Supplementation with AA appears to be able to both prevent and treat respiratory and systemic infections [3,7]. Prophylactic prevention of infection requires dietary AA intakes that provide at least adequate, if not saturating plasma levels (i.e., 100-200 mg/day), which optimize cell and tissue levels [1].

References

  1. Padayatty SJ and Levine M. “Vitamin C physiology: the known and the unknown and Goldilocks”. Oral Diseases 6 (2016): 463-493.
  2. Carr AC and Maggini S. “Vitamin C and Immune Function”. Nutrients 911 (2017): 1211.
  3. Hemilä H. “Vitamin C and Infections”. Nutrients4 (2017): 339.
  4. Liugan M and Carr AC. “Vitamin C and Neutrophil Function: Findings from Randomized Controlled Trials”. Nutrients9 (2019): 2102.
  5. Pullar JM., et al. “The Roles of Vitamin C in Skin Health”. Nutrients8 (2017): 866.
  6. Manning J., et al. “Vitamin C Promotes Maturation of T-Cells”. Antioxidants and Redox Signaling 17 (2013): 2054-2067.
  7. Garaiova I., et al. “Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study”. European Journal of Clinical Nutrition 3 (2015): 373-379.
  8. Yakoot M and Salem A. “Efficacy and safety of a multiherbal formula with vitamin C and zinc (Immumax) in the management of the common cold”. International Journal of General Medicine 4 (2011): 45-51.
  9. Hemilä Banerjee D and Kaul D. “Combined inhalational and oral supplementation of ascorbic acid may prevent influenza pandemic emergency: A hypothesis”. Nutrition1 (2010): 128-132.
  10. Kim Y., et al. “Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection”. Immune Network 2 (2013): 70-74.
  11. Bissell MJ., et al. “Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus”. Proceedings of the National Academy of Sciences of the United States of America 5 (1980): 2711-2715.
  12. Harakeh S., et al. “Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells”. Proceedings of the National Academy of Sciences of the United States of America 87 (1990): 7245-7249.
  13. Kaul D and Baba MI. “Genomic effect of vitamin ‘C’ and statins within human mononuclear cells involved in atherogenic process”. European Journal of Clinical Nutrition 59 (2005): 978-981.
  14. Kaul D., et al. “Importance of LXR-α transcriptome in the modulation of innate immunity”. Molecular and Cellular Biochemistry 292 (2006): 53-57.
  15. Wang H., et al. “c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle”. Oncogene 27 (2008): 1905-1915.
  16. Furuya A., et al. “Antiviral effects of ascorbic and dehydroascorbic acids in vitro”. International Journal of Molecular Medicine 22 (2008): 541-545.
  17. Carr A and Frei B. “Does vitamin C act as a pro-oxidant under physiological conditions?” The FASEB Journal 13 (1999): 1007-1024.
  18. Uozaki M., et al. “Antiviral effects of dehydroascorbic acid”. Experimental and Therapeutic Medicine 6 (2010): 983-986.
  19. Jöbsis RQ., et al. “Hydrogen peroxide in breath condensate during a common cold”. Mediators of Inflammation 10 (2001): 351-354.
  20. Yeo SJ., et al. “Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells”. Archives of Virology 144 (1999): 1361-1370.
  21. Hernández Guerrero CA., et al. “Vitamin C decreases MMP-9 synthesis induced by hydrogen peroxide in an in vitro chorioamniotic membrane model”. Ginecologia y Obstetricia de Mexico 74 (2006): 3-12.
  22. Wybieralska E., et al. “Ascorbic acid inhibits the migration of walker 256 carcinosarcoma cells”. Cellular and Molecular Biology Letters 13 (2008): 103-111.
  23. Gorton HC and Jarvis K. “The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections”. Journal of Manipulative and Physiological Therapeutics 22 (1999): 530-533.
  24. Kimbarowski JA and Mokrow NJ. “Colored precipitation reaction of the urine according to Kimbarowski (FARK) as an index of the effect of ascorbic acid during treatment of viral influenza”. Dtsch Gesundheitsw 22 (1967): 2413-2418.
  25. Ulasli M., et al. “The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family”. Molecular Biology Reports 3 (2014): 1703-1711.
Citation: Muhammad Torequl Islam. “Vitamin C Against Ncov-19 Infection: A Hope in the Pandemic COVID-19”. EC Pharmacology and Toxicology 9.3 (2021): 26-29.

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