Research Article
Volume 9 Issue 3 - 2021
Effects of Aqueous Extracts of Elaeis Guineensis Fruits on Haematological and Biochemical Parameters in Rats
Uroko Robert Ikechukwu1*, Nwuke Chinedu Paulinus1 Uchenna Oluomachi Nancy1, Agbafor Amarachi1 and Asadu Chidimma Lilian2
1Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia-State, Nigeria
2Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria
*Corresponding Author: Uroko Robert Ikechukwu,Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia-State, Nigeria.
Received: September 17, 2020; Published: February 26, 2021




Abstract

This study evaluated the haematological and biochemical effects of aqueous extracts of E. guineensis fruits on rats. In this study, 45 rats randomly distributed into 5 groups comprising 5 rats in group 1 as the normal control whereas groups 2 - 5 comprising 10 rats each served as the treatment groups. Five rats each from group 2 - 5 were treated with 100, 200, 400 and 600 mg/kg body weight of fresh and fermented aqueous extract of E. guineensis fruits respectively for 28 days. Standard methods and analytical grade chemicals and reagents were used in this study. All the extract-treated rats showed an increase in PCV count. Rats administered fermented extract (100 - 400 mg/kg/day) and fresh extract (100 mg/kg/day) showed elevated RBC counts relative to the control. Group 2 - 5 rats administered with fresh and fermented aqueous extracts of E. guineensis respectively showed significant (P<0.05) increase in WBC counts with increasing doses of the extracts when compared with the control. Only group 2 rats that received fresh extract showed significant (P<0.05) increase in haemoglobin (Hb) concentration while groups 4 and 5 rats treated with fresh and fermented aqueous extracts of E. guineensis respectively showed significant (P < 0.05) decrease in Hb concentrations relative to the control. Significant (P < 0.05) dose-dependent increase in lactate dehydrogenase (LDH) and gamma glutaryl transferase (GGT) activities were observed in all the rats treated with graded doses of the extracts except for group 2 treated with a fresh aqueous extract that showed significant (P < 0.05) decrease in GGT activities. The histomorphology of the hearts observed in the rats showed that the rats treated with 100 - 400 mg/kg/day of the extracts had normal histomorphology. Rats treated with 600 mg/kg/day of fresh and fermented extracts respectively showed multifocal areas of myocardial degeneration and necrosis. The findings of this study indicate that ingestion of high doses of aqueous extract of E. guineensis fruits could negatively alter haematological indices, cardiac functions and morphology as demonstrated by the significant increase in LDH and GGT activities in the treated rats.

Keywords : E. guineensis Fruits; Haematology; Lactate Dehydrogenase; Gamma Glutaryl Transferase; Heart Histology

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Citation: Uroko Robert Ikechukwu., et al. “Effects of Aqueous Extracts of Elaeis Guineensis Fruits on Haematological and Biochemical Parameters in Rats”. EC Pharmacology and Toxicology 9.3 (2021): 11-25.

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