Research Article
Volume 9 Issue 2 - 2021
Investigation of Hypoglycemic Effects of Sonchus oleraceus (Moleta) in Normal Albino Rats
Imad Eldin Mohamed Tag Eldin3, Ezdihar Elhadi Elamin Ahmed2, Mai Abdalla Ali*1 Awad Mohamed Abdel-Rahim2 and Ivan Kahwa4,5
1Department of Biochemistry and Molecular Biology, Faculty of Science, University of Gezira, P.O Box, Wad Medani, Sudan
2Center of Bioscience and Biotechnology, Faculty of Engineering and Technology, University of Gezira, P. O Box, Wad Medani, Sudan
3Department of Pharmacognosy, Faculty of Pharmacy, University of Gezira, P.O Box, Wad Medani, Sudan
4Pharm-Biotechnology and Traditional Medicine Centre of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, Mbarara, Uganda
5Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
*Corresponding Author: Mai Abdalla Ali, Department of Biochemistry and Molecular Biology, Faculty of Science, University of Gezira, P.O Box, Wad Medani, Sudan.
Received: November 18, 2020; Published: January 29, 2021




Abstract

The purpose of the study was to investigate the hypoglycemic effects of ethanolic and hexane extracts of Sonchus oleraceus in normal albino rats using fasting blood glucose and glucose tolerance tests. About 200 g leaves of S. oleraceus were macerated in 2 liters of hexane for two days, filtered and evaporated to dryness. Sixty albino rats were divided into six groups. Negative control group received water (5ml) and the positive control group administered by glibenclamide (5 mg/kg) which is known to increase insulin release from pancreatic β- cell. Four test groups received two doses (150 and 300mg/kg) of hexane extract and hydroethanolic extract of S. oleraceus leaves. Hydroethanolic extract (150, 300 mg/kg) produced insignificant reduction in blood glucose level (P-value = 0.2492, 0.1345), while hexane extract showed significant reduction (P-value = 0.001) in fasting blood glucose, moreover, hexane extract showed a significant reduction in blood glucose level when using the glucose tolerance test (P-value = 0.3173, 0.0305). It was evident that S. oleraceus leaves revealed significant hypoglycemic effects thus, it could be used as a dietary supplement for type two diabetic patients.

Keywords: Sonchus Oleraceus; Hypoglycemic; Diabetes Mellitus; Hydroethanolic; Hexane

References

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Citation: Mai Abdalla Ali., et al. “Investigation of Hypoglycemic Effects of Sonchus oleraceus (Moleta) in Normal Albino Rats”. EC Pharmacology and Toxicology 9.2 (2021): 45-50.

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