Research Article
Volume 9 Issue 4 - 2021
Effects on Bodyweight, Organ Weight and Kidney Function of Sub-Chronic Fluoride Exposure, and the Role of Moringa stenopetala Extract in Mice
Moyeta Bariso Gare1*, Teshome Gobana1, Mohammed Ibrahim Sadik1, Amare Desselegn Wolide1, Tilahun Alemayehu Nigatu2, Mesele Bezabih3, Dechassa Tegegne4 and Amare Abera Tareke1
1Department of Biomedical Sciences, Physiology Unit, Jimma University, Jimma, Ethiopia
2Department of Biomedical Sciences, Anatomy Unit, Jimma University, Jimma, Ethiopia
2Department of Pathology, Jimma Medical Center, Jimma University, Jimma, Ethiopia
2Department of Veterinary Medicine, Jimma University, Jimma, Ethiopia
*Corresponding Author: Moyeta Bariso Gare, Department of Biomedical Sciences, Physiology Unit, Jimma University, Jimma, Ethiopia.
Received: August 15, 2020; Published: March 31, 2021


Fluoride in excess is a toxic chemical to the kidney function. Studies implicated that aggravating oxidative stress and inhibiting body antioxidative systems is the main route of damage. Moringa stenopetala is rich in antioxidants and has a potent anti-oxidative effect. The study aimed to determine the effect of sub-chronic exposure to fluoride and the effect of Moringa stenopetala crude extract on body weight and kidney function. Randomized control study was conducted using 2 months old, 24 adult Swiss Albino mice. All animals were allowed free access to standard pellet diet ad libitum and distilled water. The mice were randomly divided into six groups of four animals, taking different doses of fluoride and the crude extract. After 3 months of exposure, the mice were anesthetized and sacrificed under anesthesia for sample collection. There was a statistically significant difference in renal function test (plasma urea) between the treated and the control groups in high dose fluoride group. Independent t-test yields no significant difference body mass and organ mass between fluorotic groups without Moringa stenopetala and fluorotic with Moringa stenopetala groups (P = 0.318). Though, there was some evidence indicating Moringa stenopetala might provide some protection, further studies are necessary to explore the role of Moringa stenopetala, as no significant difference was observed between groups with and without the plant extract in this study.

Keywords: Fluorosis; Sodium Fluoride; Renal Function; Moringa stenopetala; Weight; Mice


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Citation: Moyeta Bariso Gare., et al. “Effects on Bodyweight, Organ Weight and Kidney Function of Sub-Chronic Fluoride Exposure, and the Role of Moringa stenopetala Extract in Mice”. EC Pharmacology and Toxicology 9.4 (2021): 01-10.

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