Mini Review
Volume 9 Issue 1 - 2021
Dexamethasone as Repurposing Drug and the Possibility of Its Mitigating Role on NRF2-Dependent Anti-SARS-Cov2 Effect
Morshedul Alam*
Department of Genetic Engineering and Biotechnology, Bangabandhu Sheikh Mujibur Rahman Maritime University, Dhaka, Bangladesh, South Asia
*Corresponding Author: Morshedul Alam, Department of Genetic Engineering and Biotechnology, Bangabandhu Sheikh Mujibur Rahman Maritime University, Dhaka, Bangladesh, South Asia.
Received: November 28, 2020; Published: December 30, 2020


SARS-CoV2 infection is a fatal case of pandemic disease, which is the burning issue all over the world. Scientists are trying to prevent the disease pathology and in this case scientists are focusing on drug repurposing concept as still now there is no selective drug for the treatment of SARS-CoV2 infection. Recent studies have proved that activation of nuclear erythroid factor 2 related factor 2 (NRF2), a master gene regulator of detoxification system, redox homeostasis and so on, showed effective treatment measure of SARS-CoV2 infection. Dexamethasone treatment as a repurposing drug for the COVID-19 treatment although shows a transient benefit but the severe health concern is it would have lots of side effect and based on previous reports, in this mini-review I explained the possible side effect relating to mitigating NRF2-dependent pathway.

Keywords: Dexamethasone, Drug repurposing, SARS-CoV2, NRF2


  1. Worl dometer Coronavirus (2020).
  2. Channappanavar R., et al. “Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology”. Seminars in Immunopathology 5 (2017): 529-539.
  3. Li W., et al. “Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus”. Nature6965 (2003): 450-454.
  4. Cantuti-Castelvetri L., et al. “Neuropilin-1 facilitates SARS-CoV2 cell entry and infectibility”. Science1126 (2020): science.abd2985.
  5. Siu KL., et al. “Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC”. The FASEB Journal 8 (2019): 8865-8877.
  6. Jatin M., et al. “The natural history, pathobiology, and clinical manifestations of SARS-CoV2 infections”. Journal of Neuroimmune Pharmacology 15 (2020): 359-386.
  7. Morshedul A. “Possibility of NRF2 activation as a priming tool against SARS-CoV2 infection”. CPQ Medicine2 (2020): 1-5.
  8. Motohashi H., et al. “Nrf2-Keap1 defines a physiologically important stress response mechanism”. Trends in Molecular Medicine11 (2004): 549-557.
  9. Goto M, et al. “Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis”. Genes to Cells6 (2015): 464-480.
  10. Garstkiewicz M., et al. “Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2- mediated gene expression”. European Journal of Immunology 47 (2017): 806-817.
  11. Greaney AJ., et al. “Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism”. Journal of Leukocyte Biology 1 (2016): 189-199.
  12. Hou Y., et al. “Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/ TXNIP complex in cerebral ischemia reperfusion injury”. Behavioural Brain Research 336 (2018): 32-39.
  13. Cernuda-Morollon E., et al. “15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit”. Journal of Biological Chemistry 276 (2001): 35530-35536.
  14. Joe MM., et al. “Nrf2 activator PB125® as a potential therapeutic agent against COVID-19”. Bio Rxiv (2020).
  15. David O., et al. “SARS-CoV2-mediated suppression of NRF2- signaling reveals potent antiviral and anti- inflammatory activity of 4-octyl-itaconate and dimethyl fumarate”. Nature Communications4938 (2020).
  16. Kobayashi EH., et al. “Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription”. Nature Communications 7 (2016): 11624.
  17. Yamamoto M., et al. “The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis”. Physiological Reviews 2 (2018): 1169-1203.
  18. Morshedul A. “Essence of Antioxidants in Aging Science: NRF2, a True Fact”. CPQ Medicine5 (2019): 01-05.
  19. Chrousos GP. “The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes”. International Journal of Obesity and Related Metabolic Disorders 24 (2000): 50-55.
  20. Revollo JR., et al. “Mechanisms generating diversity in glucocorticoid receptor signaling”. Annals of the New York Academy of Sciences 1179 (2009): 167-178.
  21. Brenner RR., et al. “Effect of dexamethasone on the fatty acid composition of total liver microsomal lipids and phosphatidylcholine molecular species”. Lipids 36 (2001): 1337-1345.
  22. Du WW., et al. “Inhibition of dexamethasone-induced fatty liver development by reducing miR-17-5p levels”. Molecular Therapy 23 (2015): 1222-1233.
  23. Liu YF., et al. “Glucocorticoid induces hepatic steatosis by inhibiting activating transcription factor 3 (ATF3)/S100A9 protein signaling in granulocytic myeloid-derived suppressor cells”. Journal of Biological Chemistry 291 (2016): 21771-21785.
  24. Morshedul A. “Two faces of glucocorticoid receptor (GR) signaling”. EC Pharmacology and Toxicology 01 (2017): 22-24.
  25. Alam MM., et al. “Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2”. Journal of Biological Chemistry 18 (2017): 7519-7530.
Citation: Morshedul Alam. “Dexamethasone as Repurposing Drug and the Possibility of Its Mitigating Role on NRF2-Dependent Anti- SARS-Cov2 Effect”. EC Pharmacology and Toxicology 9.1 (2021): 41-44.

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