Mini Review
Volume 9 Issue 1 - 2021
Dexamethasone as Repurposing Drug and the Possibility of Its Mitigating Role on NRF2-Dependent Anti-SARS-Cov2 Effect
Morshedul Alam*
Department of Genetic Engineering and Biotechnology, Bangabandhu Sheikh Mujibur Rahman Maritime University, Dhaka, Bangladesh, South Asia
*Corresponding Author: Morshedul Alam, Department of Genetic Engineering and Biotechnology, Bangabandhu Sheikh Mujibur Rahman Maritime University, Dhaka, Bangladesh, South Asia.
Received: November 28, 2020; Published: December 30, 2020




Abstract

SARS-CoV2 infection is a fatal case of pandemic disease, which is the burning issue all over the world. Scientists are trying to prevent the disease pathology and in this case scientists are focusing on drug repurposing concept as still now there is no selective drug for the treatment of SARS-CoV2 infection. Recent studies have proved that activation of nuclear erythroid factor 2 related factor 2 (NRF2), a master gene regulator of detoxification system, redox homeostasis and so on, showed effective treatment measure of SARS-CoV2 infection. Dexamethasone treatment as a repurposing drug for the COVID-19 treatment although shows a transient benefit but the severe health concern is it would have lots of side effect and based on previous reports, in this mini-review I explained the possible side effect relating to mitigating NRF2-dependent pathway.

Keywords: Dexamethasone, Drug repurposing, SARS-CoV2, NRF2

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Citation: Morshedul Alam. “Dexamethasone as Repurposing Drug and the Possibility of Its Mitigating Role on NRF2-Dependent Anti- SARS-Cov2 Effect”. EC Pharmacology and Toxicology 9.1 (2021): 41-44.

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