Research Article
Volume 8 Issue 11 - 2020
Complications after One Year of Liver Transplantation among Adult Population
Faisal Al Muqbil1, Mohammad S Shawaqfeh1*, Abdullah Al-Tuwayjiri1, Lilian A Albukiri2, Mohammad Abujamal1, Abdulmalik Alkatheri1,3, Alwaleed R Alrebdi4 and Abdulkareem M Albekairy1,3
1College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
2College of Pharmacy, Prince Sattam University, Al Kharj, Saudi Arabia
3Pharmaceutical Care Services, King Abulaziz Medical City, Riyadh, Saudi Arabia
4College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
*Corresponding Author:Mohammad S Shawaqfeh, Assistant Professor, College of Pharmacy, Department of Pharmacy Practice, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Received: July 21, 2020; Published: October 09, 2020




Abstract

Background: Liver disease is a major medical problem in Kingdom of Saudi Arabia. Many complications to be encountered after liver transplant range from very serious to less complicated complications and also it differs in the onset of the complication.

Materials and Methods: We have conducted the present observational retrospective chart review study in King Abdulaziz Medical City in Riyadh, Saudi Arabia with a sample of 92 post liver transplantation patients. The following risk factors will be investigated: metabolic syndrome, low levels of high-density lipoprotein, and elevated blood pressure. The diagnosis of acute cellular rejection will be based on histological appearances. Metabolic syndrome is defined by having 3 or more of the following: fasting glucose (≥ 100 mg/dl); abdominal obesity (> 102 cm in men, > 88 cm in women); hypertriglyceridemia (≥ 150 mg/dl); Low levels of high density lipoprotein (HDL) (< 40 mg/dl in men, < 50 mg/dl in women) and elevated blood pressure (≥ 130/85 mmHg). Non-critical care adult inpatients who are recently admitted to the liver transplant center who are eligible for inclusion in this study.

Results: In our present study, we have included 92 patients. There were 6.7% (3 out of 45) patients who developed new onset diabetes mellitus (NODM) in our cohort during the first-year post transplantation. 10.9% (7 out of 64) patients have newly diagnosed with hypertension, and 23.0% (20 out of 87) patients developed Dyslipidemia during the first-year post transplantation.

Conclusion: The percentages of developing diabetes mellitus, hypertension and dyslipidemia are lower than the reported in different studies that might be due to lower rate of using corticosteroids in the maintenance immunosuppressive regimen, or due to intensive follow-up and maintenance immunosuppressive monitoring, or because of the good family and social support in our community. However, the patients were conveniently limited to our medical center.

Keywords: Liver Transplantation; Patients; Risk Factors; Complications; Adult Population

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Citation: Mohammad S Shawaqfeh., et al. “Complications after One Year of Liver Transplantation among Adult Population”. EC Pharmacology and Toxicology 8.11 (2020): 51-56.

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