Research Article
Volume 9 Issue 2 - 2021
Changes in Liver Oxidative Stress Biomarkers, Biochemicals and Histological Assessment in Lactating Wistar Rats Following Oral Monosodium Glutamate (MSG) Administration
Emmanuel Nachamada Solomon1*, Yaduma WG2, Kashini A3, Husainy AY4, Malgwi IS4 and Momoh IJ5
1Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University Zaria, Kaduna State, Nigeria
2Department of Chemistry, School of Life Science, Adamawa State College of Education Hong, Nigeria
3Department of Dermatology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK
4Department of Human Physiology, College of Medical Sciences, University of Maiduguri, Borno State, Nigeria
5Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Kogi State University, Anyigba, Kogi State, Nigeria
*Corresponding Author: Emmanuel Nachamada Solomon, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University Zaria, Kaduna State, Nigeria.
Received: September 01, 2020; Published: January 29, 2021


MSG consumption has been implicated in significant oxidative stress complications. Increased metabolic demand during lactation as well as increased consumption of food containing MSG by lactating mothers could predispose the liver to detrimental metabolic burden. This study evaluated the effects of MSG on oxidative stress biomarkers, albumin, total protein, liver enzymes and histology in lactating rats. At parturition, 24 adult female lactating rats were divided into four (4) groups of six animals each (n = 6). Group I served as normal control and was given distilled water (2 ml/kg BW), while group II was given metoclopramide (5 mg/kg BW). Groups III and IV were administered MSG at 1850 and 3700 (mg/kg BW) respectively for 14 days. Animals were sacrificed at the end of the experiment and samples obtained. Liver enzymes (ALT, AST and ALP), total protein and albumin were assayed from sera, whereas oxidative stress biomarkers (MDA, SOD, GSH and CAT) from liver homogenate. Histological assessment was also carried out. MDA was significantly higher (P < 0.05) in the MSG treated groups compared to control. Although the antioxidant enzymes were lower in all the treated groups compared to control, significant difference (P< 0.05) was observed in GSH and CAT only. Serum liver enzymes (ALT, AST and ALP), total protein and albumin were all significantly higher (P < 0.05) in the MSG treated groups compared to control. There was also a significant (P < 0.05) positive correlation between hepatic lipid peroxidation and all the serum liver enzymes. Hepatological alterations consisting of central vein dilation, necrosis of hepatocytes, lysis of red blood cells, sinusoidal dilatations were observed in the MSG treated groups. Thus, excessive consumption of MSG rich diets should be carried out with caution during lactation.

Keywords: Liver; Lactation; Oxidative Stress Biomarkers; Histology; Monosodium Glutamate


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