Review Article
Volume 8 Issue 10 - 2020
RNA Interference (RNAi) Technology, a New Tool for Therapy
Khairy M A Zoheir*
Professor, National Research Centre, Cell Biology Department, Genetic Engineering Division, Dokki, Egypt
*Corresponding Author: Khairy M A Zoheir, Professor, National Research Centre, Cell Biology Department, Genetic Engineering Division, Dokki, Egypt.
Received: July 08, 2020; Published: September 15, 2020


RNA interference (RNAi) is a biological process where RNA inhibits gene expression or translation by silencing targeted mRNA. The mechanism depends on double-stranded RNA (dsRNA) which makes a post transcriptional gene silencing. Small interfering RNA (siRNA) is a powerful hopeful tool in functional genomics and after showing good marker for use in future therapy, it is employing to make silencing for gene expression in mammals. siRNA is used as a protector from infection and inhibit the accessory genes and expression of antigen. Control of normal gene expression consider the main mechanism of RNAi, which its function as a therapeutic tool for a wide range of diseases, including metabolic disorders, infectious diseases and cancer. RNAi technology is still new, and its biological action on siRNA-mediated knockdown of gene expression is not yet fully understood. The development of systems for effective transfer to the target cells was one major challenge in siRNA-based therapy. Over the last few years, a number of tools were designed for DNA and RNA for gene therapy, and widespread efforts are now located into rising clinical applications of siRNAs in a range of diseases.

Keywords: RNA Interference (RNAi) Technology; mRNA; Double-Stranded RNA (dsRNA); DNA


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Citation: Khairy M A Zoheir. “RNA Interference (RNAi) Technology, a New Tool for Therapy”. EC Pharmacology and Toxicology 8.10 (2020): 32-43.

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