Research Article
Volume 8 Issue 8 - 2020
Potential Impact of Ginsenoside Rg1 on Treatment of Paclitaxel-Induced Neuropathic Pain by TNF-α Inhibitory Action
Satbir Kaur1,2 and Arunachalam Muthuraman2,3,4*
1Department of Pharmacology, Chaudhary Devi Lal College of Pharmacy, BD Sharma University of Health Science, Yamuna Nagar, Yamuna Nagar, Haryana, India
2Department of Pharmacology and Toxicology, Akal College of Pharmacy and Technical Education, Research Scholar of IK Gujral Punjab Technical University (Kapurthala), Mastuana Sahib, Sangrur, Punjab, India
3Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India
4Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, Bedong, Kedah Darul Aman, Malaysia
*Corresponding Author: Arunachalam Muthuraman, Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, Bedong, Kedah Darul Aman, Malaysia.
Received: March 25, 2020; Published: July 31, 2020


Ginsenoside Rg1 (GRg) is a major bioactive of a ginseng plant. It is a flavonoid type of natural medicine. In this research work investigated to find the therapeutic action of GRg on paclitaxel (PT) associated neuropathic pain and tumor necrosis factor-alpha (TNF-α) regulatory action. The injection of PT (2 mg/kg, i.p.) for 5 days enhances the progression of neuropathic pain. The GRg dose 5 and 10 mg/kg; intravenous (i.v.) and pregabalin (5 mg/kg; i.v.) were administered for 10 consecutive days. The algesic responses were assessed by pinprick and plantar tests in paw dorsal surface; tail-flick test; and tail pinch test. These tests were assessed at days 0, 4, 8, 12 and 16. The biomarker changes i.e. superoxide anion, myeloperoxidase, and TNF-α protein level were estimated in sciatic nerve tissue. Further, the level of TNF-α was estimated in the serum sample and expression of TNF-α proteins studied in sciatic nerve tissue along with changes of histopathology slides. Treatment of GRg and pregabalin ameliorated the chemotherapeutic agent i.e., PT associated pain response with the control of biomarkers changes like superoxide anion, myeloperoxidase, and TNF-α protein levels and histopathological changes. GRg has potential ameliorative actions against PT induced neuropathic pain due to its free radical scavenging, anti-inflammatory; and TNF-α inhibitory actions.

Keywords: Myeloperoxidase; Neuroinflammation; Nociceptive Pain; Pregabalin, Sciatic Nerve; Tumor Necrosis Factor


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Citation: Satbir Kaur and Arunachalam Muthuraman. “Potential Impact of Ginsenoside Rg1 on Treatment of Paclitaxel-Induced Neuropathic Pain by TNF-α Inhibitory Action”. EC Pharmacology and Toxicology 8.8 (2020): 90-103.

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