Research Article
Volume 8 Issue 7 - 2020
Protective Effects of Curcuma longa (Linn) Rhizoids Ethyl Acetate Extract against Alcohol Induced Oxidative Stress and Nephrotoxicity in Female Wistar Rats
Eteng OE1*, Moses CA1, Joe-Enobong E1, Akamo AJ1, Akinloye DI1, Ugbaja RN1 and Akinloye OA1,2
11Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria
22Department of Biochemistry, University of Calabar, Calabar, Nigeria
*Corresponding Author: Eteng OE, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
Received: April 06, 2020; Published: June 25, 2020




Abstract

Aim: The aim of this study was to assess the protective effect of Curcuma longa rhizoids ethyl acetate extract (CLREAE) against alcohol-induced oxidative stress and nephrotoxicity.

Methods: Thirty female (30) Wistar rats were divided randomly into six groups. Groups 1, 2, 3, 4, 5 and 6were administered with normal saline; 20% ethanol; 100 mg of CLREAE + 20% ethanol; 200 mg of CLREAE + 20%; 350 mg of CLREAE + 20% ethanol and 350 mg of CLREAE respectively for 14 days.

Results: There was a significant (p < 0.05) decrease in the SOD, CAT and GPx activities and GSH concentration of rat treated with only 20% ethanol when compared to the normal control group, but there was a significant (P < 0.05) increase in the groups pretreated with different doses of the CLREAE when compared to groups administered with only 20% ethanol. Also, treatment with the CLREAE resulted in a significant (p < 0.05) decrease in the renal biomarkers (creatinine and urea) when compared to the normal control group. But there was a significant (p < 0.05) increase in the groups pretreated with different doses of the CLREAE when compared to groups administered with 20% ethanol only. Kidney MDA level significantly (p < 0.05) decreased in rats pretreated with different doses of CLREAE compared with the normal control. The results of the histology show that they were a physiologic recovery in the kidney tissues as groups treated with different doses of the CLREAE showed signs of protection against toxicity evident from reduced necrosis of tubular and glomerular epithelial.

Conclusion: The study suggested the CLREAE has protective effects against alcohol-induced oxidative stress and nephrotoxicity in female Wistar rats via in vivo free radical scavenging ability.

Keywords: Nephrotoxicity; CL; Curcuma longa; Oxidative Stress; Alcohol; Ethyl Acetate

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Citation: Eteng OE., et al. “Protective Effects of Curcuma longa (Linn) Rhizoids Ethyl Acetate Extract against Alcohol Induced Oxidative Stress and Nephrotoxicity in Female Wistar Rats”. EC Pharmacology and Toxicology 8.7 (2020): 68-80.

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