Research Article
Volume 8 Issue 7 - 2020
A Study to Evaluate Prescription Pattern, Adherence to Medication and Quality of Life in Indian Patients Suffering from Thyroid Disorders
Hani Patel1, Amee Pandya2, Vivek Arya3, Suhani Patel4 and Supriya Malhotra5*
1IIIrd MBBS Student, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
2Resident, Department of Pharmacology, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
3Department of Endocrinology, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
4Department of Pharmacology, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
5Professor and Head, Department of Pharmacology, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
*Corresponding Author: Supriya Malhotra, Professor and Head, Department of Pharmacology, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India.
Received: May 06, 2020; Published: June 25, 2020


Introduction: Deficiency of thyroid hormones or “Hypothyroidism” is usually managed by oral thyroid hormone replacement drugs. Whereas drugs which block synthesis or conversion of thyroid hormones are employed in “Hyperthyroidism”. Since thyroid hormones play role in many bodily functions, its disturbances affect Quality of life (QoL). Also, due to the chronic nature of thyroid disorders, treatment adherence is quiet challenging.

Objectives: To evaluate prescription pattern, QoL and patient’s adherence to treatment for thyroid disorders in Indian population.

Methodology: Case record form containing patient’s demographic, clinical profile, diagnosis, prescription drugs (with dose, duration and frequency) was noted. The QoL of each patient was assessed by a 30 item questionnaire specific for thyroid disorder. Drug adherence was tested by (4 item) Morisky Green Levine Test questionnaire. The collected case record forms and questionnaires were analyzed. P value ≤ 0.05 was considered as statistically significant.

Result: Out of 126 patients, nearly three-fourth of patients were diagnosed to be suffering from hypothyroidism (Group1; n = 94) and one-fourth (Group 2; n = 32) from hyperthyroidism. Patient demographics with respect to mean age and gender distribution (40.03 ± 14.07 years; M:F = 0.08 and 39.34 ± 11.71 years; M:F = 0.14 respectively for Group 1 and 2) was comparable. Levothyroxine for hypothyroidism followed by carbimazole for hyperthyroidism were the most prescribed drugs in our study population. Nearly 70% of thyroid patients were highly adherent to medication in both the groups (Group 1 - 69.14%; Group 2 68.75%), possibly due to oral single daily dose regime. QoL was 65% in our study population (Group 1: 64% and Group 2: 67%).The mean QoL scores and mean adherence socres were not statistically different between both the groups. We found a significant positive correlation between occupation with spiritual score, gender with psychological score and adherence with spiritual score. We also observed a significant negative correlation between age and physical score and gender and spiritual score.

Conclusion: We found 65% level of adherence and 70% QoL in our study population. Hyperthyroid patients had higher QoL but lower level of medication adherence as compared to hypothyroid. Focused educational programmes, better doctor-patient and pharmacist-patient relationships with good prescribing practices can further foster this.

Keywords: Adherence; Carbimazole; Hypothyroidism; Hyperthyroidism; Levothyroxine; Prescription Patterns; Quality of Life


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Citation: Supriya Malhotra., et al. ““A Study to Evaluate Prescription Pattern, Adherence to Medication and Quality of Life in Indian Patients Suffering from Thyroid Disorders”. EC Pharmacology and Toxicology 8.7 (2020): 57-67.

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