Research Article
Volume 6 Issue 9 - 2018
Comparative Study of the Effects of Valproic Acid Versus Colchicine on Parkinsonism Induced by Rotenone in Albino Rats
Norhan Ahmed Abuo Hashish*, Dina Mohamed Elfeky, Fleur Fathi Abd Elmoneim and Sabeha Elmandoh Hedya
Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt
*Corresponding Author: Norhan Ahmed Abuo Hashish, Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt.
Received: June 26, 2018; Published: August 03, 2018
Citation: Norhan Ahmed Abuo Hashish., et al. “Comparative Study of the Effects of Valproic Acid Versus Colchicine on Parkinsonism Induced by Rotenone in Albino Rats”. EC Pharmacology and Toxicology 6.9 (2018): 775- 797.
Abstract
The current study evidenced that model of rotenone induced Parkinsonism in rats produced degeneration of nigrostriatal dopamine neurons with increase in tumor necrosis factor α, decrease in reduced glutathione and dopamine levels. This was confirmed by behavioral tests (catalepsy score, pole test, T-maze test) measured at 7th, 14th, 21st and 28th days and neurochemical parameters. Moreover, histopathological examination of basal ganglia as structural damage with lewy bodies and immunohistochemistry indicated presence of caspase-3 that are typical features of undergoing apoptosis. Administration of L-dopa as replacement therapy caused improvement in behavioral tests and neurochemical parameters. Other drugs used as Colchicine and valproic acid to improve anti-parkinsonian and neuroprotective effects. In this study Colchicine exhibited excellent neuroprotective effect by anti-oxidant, anti-inflammatory and anti-apoptotic properties on valproic acid by improvement of behavioral tests and neurochemical parameters with preservation of dopaminergic basal ganglion cells integrity and absence of caspase-3 expression in immunohistochemistry. In conclusion Colchicine could be recommended in Parkinsonism therapy early in course of the disease.
Keywords: Parkinsonism; Rotenone; L-Dopa; Colchicine; Valproic Acid; Apoptosis
Copyright: © 2018 Norhan Ahmed Abuo Hashish., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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