Research Article
Volume 6 Issue 9 - 2018
Comparative Study of the Effects of Valproic Acid Versus Colchicine on Parkinsonism Induced by Rotenone in Albino Rats
Norhan Ahmed Abuo Hashish*, Dina Mohamed Elfeky, Fleur Fathi Abd Elmoneim and Sabeha Elmandoh Hedya
Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt
*Corresponding Author: Norhan Ahmed Abuo Hashish, Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt.
Received: June 26, 2018; Published: August 03, 2018
Citation: Norhan Ahmed Abuo Hashish., et al. “Comparative Study of the Effects of Valproic Acid Versus Colchicine on Parkinsonism Induced by Rotenone in Albino Rats”. EC Pharmacology and Toxicology 6.9 (2018): 775- 797.
Abstract
The current study evidenced that model of rotenone induced Parkinsonism in rats produced degeneration of nigrostriatal dopamine neurons with increase in tumor necrosis factor α, decrease in reduced glutathione and dopamine levels. This was confirmed by behavioral tests (catalepsy score, pole test, T-maze test) measured at 7th, 14th, 21st and 28th days and neurochemical parameters. Moreover, histopathological examination of basal ganglia as structural damage with lewy bodies and immunohistochemistry indicated presence of caspase-3 that are typical features of undergoing apoptosis. Administration of L-dopa as replacement therapy caused improvement in behavioral tests and neurochemical parameters. Other drugs used as Colchicine and valproic acid to improve anti-parkinsonian and neuroprotective effects. In this study Colchicine exhibited excellent neuroprotective effect by anti-oxidant, anti-inflammatory and anti-apoptotic properties on valproic acid by improvement of behavioral tests and neurochemical parameters with preservation of dopaminergic basal ganglion cells integrity and absence of caspase-3 expression in immunohistochemistry. In conclusion Colchicine could be recommended in Parkinsonism therapy early in course of the disease.
Keywords: Parkinsonism; Rotenone; L-Dopa; Colchicine; Valproic Acid; Apoptosis
Copyright: © 2018 Norhan Ahmed Abuo Hashish., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PubMed Indexed Article

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


News and Events

Best Article of the Issue

The Editors of respective journals will elect one Best Article after each issue release and the authors of the selected article will be provided with a certificate of "Best Article of the Issue".

Submission Timeline for April Issue

E-Cronicon delightfully welcomes the authors for submission of novel research towards May issue of respective journals. Submissions are accepted on/before April 26, 2019.

Certification for each Publication

Corresponding Authors will be issued a "Publication Certificate" with all the Co-Authors included as a token of appreciation for publishing their work with respective journals.

Certifying for Review

E-Cronicon certify the Editors for their first review done towards respective journals.

Latest Articles

Recently published articles will be updated immediately after publication in respective journals.