Research Article
Volume 6 Issue 8 - 2018
Antioxidant Activity of Rosa damascena in Isoproterenol Induced in Oxidative Stress in Rats
C Venkata Ramana Reddy*, KP Priyanka, CP Pullaiah and D Ranganayakulu
Department of Pharmacology, Sri Padmavathi School of Pharmacy, Tirupati, Andhra Pradesh, India
*Corresponding Author: C Venkata Ramana Reddy, Department of Pharmacology, Sri Padmavathi School of Pharmacy, Tirupati, Andhra Pradesh, India.
Received: June 08, 2018; Published: July 06, 2018
Citation: C Venkata Ramana Reddy., et al. “Antioxidant Activity of Rosa damascena in Isoproterenol Induced in Oxidative Stress in Rats”. EC Pharmacology and Toxicology 6.8 (2018): 645-650.
Abstract
Anti-oxidant activity of ethanolic extract of Rosa damascena (200 and 400 mg/kg b.wt, orally for 28 days) against isoproterenolinduced oxidative stress was investigated in rats. In addition to the activities of the antioxidant enzymes-glutathione reductase, superoxide dismutase, catalase and lipid peroxidase in the heart tissue. Administration of isoproterenol increased the level of lipid peroxides with corresponding decrease in the activities of the non-enzymatic antioxidants. The pre-treatment with ethanolic extract of petals significantly prevented the alterations induced by isoproterenol, and maintained near normal antioxidant status. Results suggest that the cardioprotective effect of Rosa damascena may partly be attributed to its antioxidant properties.
Keywords: Myocardial Infraction; Cardio Protection; Biomarkers; Antioxidants
Copyright: © 2018 C Venkata Ramana Reddy., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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