Research Article
Volume 11 Issue 6 - 2022
The Incidence and Clinical Characteristics of Pulmonary Embolism (PE) in Oncologic Patients: Cohort Study
Mohamed Abdelgwad Habeb1*, Mohamed Fouad Abdelmohsen2, Abdulmajeed Mualla Alotaibi3, Dhafer Abdullah Alshehri4, Ahmed Hamza Mohammed Alhadi5, Afaf Shuaib Albaqawi6, Abdullah Mansour Alassaf6 and Mohammed Rajeh Alshehri7
1Pulmonology Consultant, Ministry of Health KSA, Madinah, Saudi Arabia
2Lecturer of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt and Senior Registrar of Medical Oncology, King Fahad Hospital, Almadinah, Saudi Arabia
3R4 Senior Internal Medicine Resident, Ministry of Interior-KSA, Riyadh, Saudi Arabia
4Registrar of Internal Medicine, Ministry of Interior-KSA, Riyadh, Saudi Arabia
5R4 Senior Internal Medicine Resident, Ministry of National Guard-Health Affairs, Madinah, Saudi Arabia
6Senior Resident Internal Medicine, Ministry of Health-KSA, Riyadh, Saudi Arabia
7R3 Senior Internal Medicine Resident, Ministry of Health-KSA, Riyadh, Saudi Arabia
*Corresponding Author: Mohamed Abdelgwad Habeb, Pulmonary Medicine, King Fahad Hospital, Almadinah, Saudi Arabia.
Received: June 22, 2022; Published: June 28, 2022


Background: The clinical characteristics of pulmonary embolism (PE) in Oncological outpatients for different types of cancer are unknown.

Purpose of the Study: To estimate the incidence and type of pulmonary embolism among oncologic patients with an assessment of related clinical characteristics.

Patient and Methods: Prospective cohort study was carried out on (540) patients with different cancers at one day care unit of the oncology department at king Fahd hospital, Kingdom of Saudi Arabia. CT chest with contrast and CT pulmonary angiography was done when indicated.

Results: Our study was carried out on (540) patients who have different cancers, of which 24 (4.44%) developed PE. PE group was 9 (37.5%) males while 15 (62.5%) females with M ± SD of age (54.95 ± 17.3). PE was represented (50%) of patients with seminoma, germ cell tumor while larynx Cancer was represented (33.4%) and less common in colon, prostate, and breast Cancers (6.68%, 4.7%, 2.54%) respectively. 7 PE patients (1.3%) were incidentally discovered during the staging of cancer while 17 patients (3.14%) have symptomatic PE. In the symptomatic group: (10) patients developed PE during chemotherapy, (4) patients developed PE during hormonal therapy, (2) patients developed PE during the staging of cancer and (1) patients developed PE during follow-up after chemotherapy. 20/24 (84%) of PE developed in the first 6 months from diagnosis of cancer while 4/24 (16%) of PE developed during follow up of the patients within the first year from diagnosis patients had cancer prostrate, one patient has cancer larynx and one patient has cancer breast. The most degree of PE was low-risk PE (75%) while massive and sub-massive were in (3) patients (12.5%) each. Most of the patients were given low molecular weight heparin (LMWH) (22/24) patients while thrombolytic therapy (TPA) was given for only one patient and IVC filter was inserted in 2 patients.

Conclusion: Among oncological patients in outpatients' settings with Different Types of Cancers, PE incidence was 4.4% with Most common of these were seminoma, germ cell tumor, prostate, lung, and larynx cancers but the least common in Breast Cancer. Noted that patients with (lung, pancreas, uterus, and bladder) cancer have a higher risk of Incidental PE. Low-risk PE type was the most common, while sub-massive and Massive were rare.

Keywords: PE; Different Cancer Type; Characters; Oncology; Outpatient


  1. Griffiths GO., et al. “FRAGMATIC: A randomised phase III clinical trial investigating the effect of fragmin {sup®} added to standard therapy in patients with lung cancer”. BMC Cancer (2009): 9.
  2. Lee AYY., et al. “Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer”. The New England Journal of Medicine2 (2003): 146-153.
  3. Bloom J., et al. “The risk of venous thrombosis in cancer patients with or without the factor V Leiden mutation”. Haemostasis1 (2001): 73.
  4. Zuckerman E., et al. “Increased thromboembolic incidence in anti-cardiolipin-positive patients with malignancy”. British Journal of Cancer 2 (1995): 447-451.
  5. Perry JR., et al. “PRODIGE: a randomized placebo‐controlled trial of dalteparin low‐molecular‐weight heparin thromboprophylaxis in patients with newly diagnosed malignant glioma”. Journal of Thrombosis and Haemostasis 9 (2010): 1959-1965.
  6. Chew HK., et al. “Incidence of venous thromboembolism and its effect on survival among patients with common cancers”. Archives of Internal Medicine 4 (2006): 458-464.
  7. Blom JW., et al. “High risk of venous thrombosis in patients with pancreatic cancer: a cohort study of 202 patients”. European Journal of Cancer 3 (2006): 410-414.
  8. Farrell C., et al. “Unsuspected pulmonary embolism identified using multidetector computed tomography in hospital outpatients”. Clinical Radiology 1 (2010): 1-5.
  9. Ghaye B., et al. “Can CT pulmonary angiography allow assessment of severity and prognosis in patients presenting with pulmonary embolism? What the radiologist needs to know”. Radiographics1 (2006): 23-39.
  10. Desai SR. “Unsuspected pulmonary embolism on CT scanning: yet another headache for clinicians? Thorax”. BMJ Publishing Group Ltd 62 (2007): 470-472.
  11. Konstantinides SV., et al. “2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of”. European Heart Journal 4 (2020): 543-603.
  12. Reynolds MW., et al. “Impact of clinical trial design and execution-related factors on incidence of thromboembolic events in cancer patients: a systematic review and meta-analysis”. Current Medical Research and Opinion 2 (2008): 497-505.
  13. Khorana AA and Connolly GC. “Assessing risk of venous thromboembolism in the patient with cancer”. Journal of Clinical Oncology 29 (2009): 4839.
  14. Agnelli G., et al. “A clinical outcome-based prospective study on venous thromboembolism after cancer surgery: the@ RISTOS project”. Annals of Surgery 1 (2006): 89.
  15. Biedka M., et al. “Acute pulmonary embolus in the course of cancer”. Contemporary Oncology 5 (2012): 388-393.
  16. Stein PD., et al. “Incidence of venous thromboembolism in patients hospitalized with cancer”. The American Journal of Medicine 1 (2006): 60-68.
  17. Khorana AA., et al. “Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients”. Cancer10 (2007): 2339-2346.
  18. Karippot A., et al. “The clinical characteristics of pulmonary embolism in patients with malignancy: a single medical institutional experience”. North American Journal of Medical Sciences 11 (2012): 600-604.
  19. Abdel-Razeq HN., et al. “Incidental pulmonary embolism in cancer patients: clinical characteristics and outcome--a comprehensive cancer center experience”. Vascular Health and Risk Management 7 (2011): 153-158.
  20. Dentali F., et al. “Prevalence and clinical history of incidental, asymptomatic pulmonary embolism: a meta-analysis”. Thrombosis Research 6 (2010): 518-522.
Citation: Mohamed Abdelgwad Habeb., et al. “The Incidence and Clinical Characteristics of Pulmonary Embolism (PE) in Oncologic Patients: Cohort Study”. EC Pulmonology and Respiratory Medicine 11.6 (2022): 44-49.

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