Review Article
Volume 10 Issue 11 - 2021
Role of Immunity in Management of Chronic Rhinosinusitis and Allergic Rhinitis in Current Trying Times Like COVID-19
Makharia S1, Dhond P2, Archana Karadkhele3*, Muchhala S1 and Rathod R3
1Department of Otorhinolaryngology, Jaslok Hospital and Research Centre, Mumbai, India
2Department of Otorhinolaryngology, Sai Krupa ENT Nursing Home, Mumbai, India
3Department of Medical Affairs, Dr Reddy’s Laboratories, Hyderabad, Telangana, India
*Corresponding Author: Archana Karadkhele, Department of Medical Affairs, Dr Reddy’s Laboratories, Hyderabad, Telangana, India.
Received: September 28, 2021; Published: October 29, 2021


The burden of COVID-19 is increasing all over the world. Patients affected with COVID-19 with a previous history of comorbidities, such as respiratory illnesses, are at a higher risk for severe illness, resulting in adverse outcomes. Up-regulation of the immune system by immunomodulators is crucial in the current scenario in India, especially in patients with recurrent respiratory tract infections such as allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Current management options for AR and CRS include allergen avoidance and use of second-generation antihistamines (such as fexofenadine), leukotriene receptor antagonist (montelukast), and intranasal corticosteroids (INCS) aim for symptomatic relief. Antibiotics, such as azithromycin and amoxicillin–clavulanate (AMC), are prescribed for patients with CRS to treat acute bacterial exacerbations of CRS. Pidotimod is a potent allopathic immunomodulator available in India with proven clinical benefits in adult patients with respiratory infections in primary and secondary immune deficiencies. Studies have shown that Pidotimod adjuvant therapy can prevent cytokine cascade activation and potentiate immune responses against viruses. This consensus report summarizes expert opinion and views on the use of Pidotimod in trying times like COVID-19 in patients with mild-to-moderate symptoms of COVID-19 disease and in adult patients with a risk or established history of AR and CRS.

Keywords: COVID-19; SARS-Cov-2; Pidotimod; India; ENT; Chronic Rhinosinusitis; Allergic Rhinitis; Expert Opinion


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Citation: Makharia S., et al. “Role of Immunity in Management of Chronic Rhinosinusitis and Allergic Rhinitis in Current Trying Times Like COVID-19”. EC Pulmonology and Respiratory Medicine 10.11 (2021): 54-61.

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