Mini Review
Volume 10 Issue 4 - 2021
Cytokine Storm: A Threatening Challenge for COVID-19 Infected Patients
Petar Avramovski*
Professor of High Medical School and Veterinary Medicine Faculty at University St. Clement of Ohrid and Primarius, Specialist of Internal Medicine at Clinical Hospital - Bitola, Bitola, Macedonia
*Corresponding Author: Petar Avramovski, Professor of High Medical School and Veterinary Medicine Faculty at University St. Clement of Ohrid and Primarius, Specialist of Internal Medicine at Clinical Hospital - Bitola, Bitola, Macedonia.
Received: March 04, 2021; Published: April 06, 2021


Cytokine storm (CV) is result of uncontrolled emission of cytokines under stimulation of infective agent. In fatal COVID-19 infection is represented by acute respiratory distress syndrome (ARDS), pneumonia, hypercoagulation and multiorgan dysfunctions. The characteristics of CS are capillaries leakage, tissue edema, which result with organ failure and shock, associated with excessive immune response reaction which is triggered by activation of T-helper 1 reactions. Early detection of interleukin-6 (IL-6) in patients with COVID-19 infection is helpful for early prediction of illness severity. Extracorporeal blood ultrafiltration by hemofilter AN69ST (oXiris®) absorb IL-6, systemic hyperinflammation and coagulopathy and accelerate clinical recover of the COVID-19 patients.


Keywords: SARS-CoV-2; Acute Respiratory Distress Syndrome (ARDS); Cytokine Storm (CV); COVID-19


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Citation: Petar Avramovski. “Cytokine Storm: A Threatening Challenge for COVID-19 Infected Patients”. EC Pulmonology and Respiratory Medicine 10.5 (2021): 11-14.

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