Research Article
Volume 10 Issue 3 - 2021
Ostojic Olivera1, Milosević Katarina2,3, Sagić Lidija4, Djuretic A5, Zivanovic Snezana6,7, Kostic Gordana8,9, Ivana Filipovic10, Vekovic Vesna1 and Zivkovic Zorica1,11*
Alexandru C Grigorescu*
1Children’s Hospital for Lung Diseases and Tuberculosis, Medical Center “Dr Dragisa Misovic”, Belgrade, Serbia
2University Children`s Hospital Belgrade, Serbia
3Faculty of Medicine, University of Belgrade, Serbia
4Municipal Institute for Lung Disease and Tuberculosis Belgrade, Serbia
5Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia
6Children Clinic, Clinical Center Niš, Niš, Serbia
7Faculty of Medicine, University of Niš, Niš, Serbia
8Children Clinic, Clinical Center Kragujevac, Kragujevac, Serbia
9Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia
10Hospital for Gynecology and Obstetrics, Medical Center “Dr Dragisa Misovic”, Belgrade, Serbia
11Faculty of Pharmacy, University Business Academy in Novi Sad, Novi Sad, Serbia
*Corresponding Author: Zorica Zivkovic, Children’s Hospital for Lung Diseases and Tuberculosis, Medical Center “Dr Dragisa Misovic”, Belgrade, Serbia.
Received: January 27, 2021; Published: February 27, 2021


Introduction and Objective: Allergic rhinitis (AR) is one of the common diseases among children. Through childhood, AR prevalence is between 30% to 40% in children and adolescents. It is usually underdiagnosed because the symptoms are nonspecific and accountable to recurrent colds. It has a negative impact on quality of life. The aim of this study is to evaluate the efficacy and safety of this natural nasal spray for symptoms relief in children with AR.

Patients and Methods: The study was conducted in the period from August 2017 to March 2018 as a multicentre, prospective study among 237 pediatric patients age 3 to 18 with allergic rhinitis. At the first visit, we took medical history data, demographic data, clinical symptoms (nasal congestion, itchy nose and eyes, sleepiness, duration of symptoms, time of occurrence), clinical examination was conducted and also allergy skin prick test and nasal swab. The children were given PropoMucil® allergy nasal spray (combination of standardized propolis with 12% of polyphenol and N-acetylcysteine, quercetin, thyme and eucalyptus essential oil and vitamin D3 and E; Abela Pharm, Belgrade, Serbia) to use it. Our patients used nasal spray, daily, for 30 days. At the second visit, patients fill out the questionnaire- about symptoms, therapy efficiency, favorability of spray taste, adverse effect.

Results: Out of the 237 patients, 60% were boys and 50% of children had up to 9 years. At the first visit, vast majority of the parents/caregivers - 90% of them, reported nasal obstruction in children, nasal itching in 69% and sneezing in 68%, fatigue and sleepiness in 22%. The allergy test was performed in 94% participants.

Persistent type of AR had 58% children. Moderate type of AR had 58% children, and 42% had mild form. Only 3% of children previously did not receive any treatment, while 97% were treated with antihistamines and/or nasal corticosteroid therapy. After 30 days therapy with PropoMucil® allergy nasal spray, number of subjects with no nasal itching was 55% and no nasal congestion, 60%. 7% of children reported adverse effects: tingling nose, nasal bleeding, watery eyes, itchy nose, sneezing.

Conclusion: The combination propolis, N-acetylcysteine, quercetin, thyme and eucalyptus essential oil and vitamin D3 and E in nasal spray is a good choice for the treatment of allergic rhinitis in children. About 80% of parents said that this nasal spray improved overall health in their children.


Keywords: Allergic Rhinitis; Nasal Congestion; Children; Propolis; N-Acetylcysteine


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Citation: Zivkovic Zorica., et al. “Efficacy and Safety of Unique Natural Combination Spray for Symptoms Relief in Children with Allergic Rhinitis”. EC Pulmonology and Respiratory Medicine 10.3 (2021): 76-86.

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