Volume 10 Issue 2 - 2021
COVID-19 Influencing Thyroid Dysfunction
Porntep Siriwanarangsun1, Attapon Cheepsattayakorn1,2* and Ruangrong Cheepsattayakorn3
1Faculty of Medicine, Western University, Pathumtani Province, Thailand
210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand
3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.
Received: December 15, 2020; Published: January 25, 2021

Recently, a first case-report of thyroid dysfunction following SARS-CoV-2 (COVID-19) infection, namely subacute thyroiditis was reported [1]. This female patient had a painful, enlarged thyroid gland [2]. The exact mechanisms that SARS-CoV-2 (COVID-19) causes thyroid dysfunction are not known. Nevertheless, mechanisms that are demonstrated through SARS virus are potential central mechanism [3-5], direct viral replication [6-9], interaction with thyroid-ACE2 receptor [10-12], and inflammatory response, apoptosis, and local damage [13-16]. SARS-CoV-2 (COVID-19) and thyroid dysfunction impact each other by: 1) Graves’s ophthalmopathy with actively undergoing immunosuppressive therapy are likely to increase risk of severe coronavirus infection development [17]; 2) Patients with poorly controlled thyroid dysfunction, particularly those with thyrotoxicosis, may be at risk of thyroid storm [18]; and 3) Systemic disease, including COVID-19 are related to low-T3 syndrome or non-thyroidal illness [19]. As pregnant women with hyper- or hypothyroidism are at increased risk of development of more severe COVID-19 disease, they are particularly suggested to social distancing adherence [20]. In the first trimester of pregnancy, the preferred treatment is the lowest possible dose of propylthiouracil (PTU) [21].


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  10. Liu F., et al. “ACE2 expression in pancreas may cause pancreatic damage after SARS-CoV-2 infection”. Clinical Gastroenterology and Hepatology (2020).
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  21. Alexander EK., et al. “2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum”. Thyroid 27 (2017): 315-389.
Citation: Attapon Cheepsattayakorn., et al. “COVID-19 Influencing Thyroid Dysfunction”. EC Pulmonology and Respiratory Medicine 10.2 (2021): 20-21.

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