Mini Review
Volume 9 Issue 11 - 2020
Down Syndrome and Covid-19: Mini Review
Ananya Mehta and Alok S Shah*
Pulmonary Department, University of Chicago, USA
*Corresponding Author: Alok S Shah, Pulmonary Department, University of Chicago, USA.
Received: October 07, 2020; Published: October 22, 2020


Down syndrome (DS), also known as trisomy 21 is a genetic disorder caused by irregular cell division occurring on chromosome number 21 [5]. People with DS are known to have a higher occurrence of autoimmune disorders, chronic immune dysregulation, impaired cell immunity, hospitalization for viral respiratory infections and higher mortality rate due to diseases related to the respiratory tract and pneumonia [26]. People with DS have immune responses that depict a strong interferon response which might only help fight off the initial COVID-19 infection, however since they have impaired cellular immunity, the infection might gain an advantage and cascade into a cytokine storm, producing excess cytokines [22]. The prevalence of Pneumonia amongst DS patients is high and amongst COVID-19 patients as well. The impact of COVID-19 on the immune system of people with DS remains unknown. However, since COVID-19 directly attacks the respiratory system, suggests why people with DS must be considered a ‘high risk’ population for the COVID-19 infection. Specifically, the impact of the immune dysregulation caused by DS which might result in an intense cytokine release syndrome relative to the symptoms of COVID-19 [1,11].

Keywords: Down Syndrome; Trisomy 21; COVID-19; Pneumonia; Immune Dysregulation; Cytokines; Interferon


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Citation: Ananya Mehta and Alok S Shah. “Down Syndrome and Covid-19: Mini Review". EC Pulmonology and Respiratory Medicine 9.11 (2020): 92-96.

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